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OG-L002

OG-L002 Structure
OG-L002
OG-L002 Property
  • Boiling point 416.7±45.0 °C(Predicted)
  • Density 1.193±0.06 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility insoluble in H2O; ≥22.5 mg/mL in DMSO; ≥6.82 mg/mL in EtOH
  • form solid
  • pka 9.78±0.10(Predicted)
  • color White to yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

OG-L002 Chemical Properties,Usage,Production

  • Description Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression. Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection. OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 μM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 μM). It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes. OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells. It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.
  • Uses OG-L002 is a novel, potent, and selective LSD1/KDM1A inhibitor that epigenetically blocks the herpes simplex lytic replication and reactivation from latency.
  • in vivo

    OG-L002 (i.p.; 6-40 mg/kg; daily; for 7 days) reduces the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection[1].

    Animal Model:4-week-old BALB/c female mice[1]
    Dosage:6, 20, 40 mg/kg
    Administration:Intraperitoneal; daily; for 7 days
    Result:Reduced the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection.
  • target LSD1
  • storage Store at -20°C
OG-L002 Preparation Products And Raw materials
Raw materials
Preparation Products
OG-L002 Suppliers
Global(106)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
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    InvivoChem
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：support@targetmol.com
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    Aladdin Scientific
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  • Email：tp@aladdinsci.com
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  • Supplier： Jinan Trio PharmaTech Co., Ltd.
  • Tel：+86 (531) 88811783
  • Email：sales@trio-pharmatech.com (International market)
  • Country：China
  • ProdList：1856
  • Advantage：62
OG-L002 Spectrum
1357302-64-7, OG-L002Related Search:
  • Inhibitors
  • 抑制剂
  • 合成有机化合物配体
  • 小分子抑制剂，天然产物
  • 化合物OG-L002,10 MM DMSO 溶液
  • OG-L002,LSD1抑制剂
  • 4'-((1R,2S)-2-氨基环丙基)-[1,1'-联苯]-3-醇
  • 化合物OG-L002
  • 4'-((1R,2S)-2-氨基环丙基)联苯-3-醇
  • 1357302-64-7
  • OG-L002, 10 mM in DMSO
  • OG-L002 USP/EP/BP
  • [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-
  • CS-830
  • OGL002;OG L002;OGL-002
  • 4'-((1R,2S)-2-Aminocyclopropyl)-[1,1'-biphenyl]-3-ol
  • 4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol
  • OG-L002 4'-((1S,2R)-2-aminocyclopropyl)-[1,1'-biphenyl]-3-ol 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol
  • OG-L002 [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-
  • [1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-o
  • OG-L002

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