Physical Form Uses
ChemicalBook > CAS DataBase List > (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

Physical Form Uses
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Structure
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
  • CAS No.915095-94-2
  • Chemical Name:(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
  • CBNumber:CB12657939
  • Molecular Formula:C17H16ClIO2
  • Formula Weight:414.67
  • MOL File:915095-94-2.mol
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Property
  • Boiling point 476.0±45.0 °C(Predicted)
  • Density 1.578±0.06 g/cm3 (20 ºC 760 Torr)
  • storage temp. 2-8°C(protect from light)
  • solubility DMSO, Methanol (Slightly, Sonicated)
  • form Solid
  • color White to Off-White
  • InChI InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1
  • InChIKey YLUHNGIWRCCQMQ-INIZCTEOSA-N
  • SMILES O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1
  • CAS DataBase Reference 915095-94-2
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Chemical Properties,Usage,Production

  • Physical Form Solid
  • Uses (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran(915095-94-2) can be used as reactant/reagent in preparation of C-?aryl D-?glurofuranoside compounds useful as reference compounds in the quality control of gliflozin type medicine.
  • Description (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.
  • Uses (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (compound 2d), a halogenated Phenstatin analog, is a microtubule destabilizing agent. (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran shows anticancer activities[1].
  • Preparation 0.5 mol of (S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (also known as (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran) was obtained through purification.
    (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
  • References [1] Hu, S., et al. Design, synthesis and anticancer activities of halogenated Phenstatin analogs as microtubule destabilizing agent. Med Chem Res 28, 465–472 (2019).
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Suppliers
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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Spectrum
915095-94-2, (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuranRelated Search:
  • 915095-94-2
  • Empagliflozin Intermediate
  • Empagliflozin
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  • 杂质对照品
  • 化工原料及中间体
  • 高端化学
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  • 伊帕列净中间体
  • 恩格列净
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  • 艾拉列净中间体
  • 中间体
  • 艾帕列净中间体
  • 依帕列净中间体
  • C17H16ClIO2
  • (3S)-3-[4-[(2-氯-5-碘苯基)甲基]苯氧基]四氢呋喃(915095-94-2)
  • 恩格列净中间体3(碘代)
  • E5碘化物/(S)-3-(4-(5-碘-2-氯苄基)苯氧基)四氢呋喃
  • EMPAGLIFLOZIN中间体II
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  • (3S)-3-{4-[(2-氯-5-碘苯基)甲基]苯氧基}噁戊环
  • 恩格列净中间体1(恩格列净杂质23)
  • (3S)-3-[4-[(2-氯-5-碘苯基)甲基]苯氧基]四氢呋喃恩格列净中间体
  • (3S)-3-[4-[(2-氯-5-碘苯基)甲基]苯氧基]四氢呋喃(3S)-3-[4-[(2-CHLORO-5-IODOPHENYL)METHYL]PHENOXY]TETRAHYDRO-FURAN
  • (3S)-3-【4-【(5碘-2-氯苯基)甲基)苯氧基】四氢呋喃
  • 依帕列净杂质110
  • 恩格列净中间体,(S)-3-(4-(5-碘-2-氯苄基)苯氧基)四氢 呋喃
  • 曲格列秦杂质C
  • (3S)-3-(4-(5-碘-2-氯苄基)苯氧基)四氢呋喃
  • 依帕列净杂质 C
  • (3S)-3-[4-[(2-氯-5-碘苯基)甲基]苯氧基]四氢呋喃(依帕列净中间体)
  • (S)-3-(4-(5-碘-2-氯苄基)苯氧基)四氢呋喃
  • (3S)-3-[4-[(2-氯-5-碘苯基)甲基]苯氧基]四氢呋喃
  • (S)-3-(4-(2-氯-5-碘苄基)-苯氧基)-四氢呋喃
  • (3S)-3-[4-[(2-氯-5-碘苯基)甲基]苯氧基]四氢呋喃(依帕列净中间体) 100G
  • (S)-3-(4-(2-氯-5-碘苯)苯氧基)四氢呋喃
  • E5碘化物
  • 915095-94-2
  • (3S)-3-(4-(5-Iodo-2-chlorobenzyl)phenoxy)tetrahydrofuran
  • (3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc
  • (3S)-3-[4-4(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
  • Empagliflozin Intermediate/ (3S)-3-[4-[(2-Chloro-5-Iodophenyl)Methyl]Phenoxy]Tetrahydro-Furan
  • (S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene
  • EMpagliflozin iMpurity C
  • (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-...
  • (3S)-3-[4-[(5-Iodo-2- Chlorophenyl) Methyl] Phenoxy] Tetrahydrofuran

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