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Amorolfine hydrochloride

Amorolfine hydrochloride Property

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Amorolfine hydrochloride Chemical Properties,Usage,Production

Uses (Rac)-Amorolfine hydrochloride is the racemic form of Amorolfine hydrochloride. Amorolfine (Ro 14-4767/002) hydrochloride (HY-B0238) is an effective antifungal agent. Amorolfine hydrochloride inhibits the biosynthesis of ergosterol and has research potential for treating onychomycosis caused by Neoscytalidium dimidiatum[1][2].
Definition ChEBI: Amorolfine hydrochloride is a hydrochloride resulting from the formal reacton of equimolar amounts of hydrogen chloride and amorolfine. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used for the topical treatment of fungal nail and skin infections. It has a role as an EC 1.14.13.132 (squalene monooxygenase) inhibitor, an EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor and an EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor. It is a hydrochloride and a morpholine antifungal drug. It contains an amorolfine(1+).
References [1] Haria M, et al. Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections. Drugs. 1995 Jan;49(1):103-20. DOI:10.2165/00003495-199549010-00008
[2] Bunyaratavej S, et al. Efficacy of 5% amorolfine nail lacquer in Neoscytalidium dimidiatum onychomycosis. J Dermatolog Treat. 2016 Aug;27(4):359-63. DOI:10.3109/09546634.2015.1109029

Amorolfine hydrochloride Preparation Products And Raw materials

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Amorolfine hydrochloride Spectrum

106614-68-0, Amorolfine hydrochlorideRelated Search:

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