Uses
trans-Permethrin is the trans isomer of Permethrin (P288500) which is a common synthetic pyrethoid insecticide with low mammalian toxicity.
Production Methods
Trans-permethrin is produced through an esterification reaction between 3-phenoxybenzyl alcohol and (1R, trans)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid, which is the trans-configured acid component. The synthesis begins with the preparation of the cyclopropane acid via cyclopropanation and chlorination, ensuring the correct trans stereochemistry. Separately, the alcohol is synthesised from 3-phenoxybenzaldehyde through reduction. These two components are then combined under controlled conditions to form the ester bond. Since permethrin consists of a mixture of cis and trans isomers, purification techniques such as recrystallisation or chromatographic separation are employed to isolate the trans isomer. This
Mechanism of action
Neurotoxin, acts on the nervous system of insects, and disturbs the function of neurons by interaction with the sodium channel.
Safety Profile
A poison by intravenous route. Moderately toxic by intraperitoneal route. Questionable carcinogen. When heated to decomposition it emits toxic vapors of Clí.
Pesticide Type
Insecticide; Veterinary substance
