DOTA-NOC, DOTA-[Nal3]-octreotide

Chemical Properties

Colourless to off-white lyophilised solid

Uses

DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging[1]. DOTA-NOC can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

IC 50

RDC Peptide

References

[1] Wild D, et al. DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals. Eur J Nucl Med Mol Imaging. 2003 Oct;30(10):1338-47. DOI:10.1007/s00259-003-1255-5
[2] JOHAN HYGUM DAM. Preparation and Evaluation of [18F]AlF-NOTA-NOC for PET Imaging of Neuroendocrine Tumors: Comparison to [68Ga]Ga-DOTA/NOTA-NOC.[J]. Molecules, 2022. DOI: 10.3390/molecules27206818