Uses
Difenoconazole-d6 (hydrochloride) is deuterium labeled Difenoconazole. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth[1][2].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:
10.1177/1060028018797110[2] Mu X, et al. Evaluation of acute and developmental effects of difenoconazole via multiple stage zebrafish assays. Environ Pollut. 2013 Apr;175:147-57. DOI:
10.1016/j.envpol.2012.12.029[3] Dong F, et al. Chiral triazole fungicide difenoconazole: absolute stereochemistry, stereoselective bioactivity, aquatic toxicity, and environmental behavior in vegetables and soil. Environ Sci Technol. 2013 Apr 2;47(7):3386-94. DOI:
10.1021/es304982m[4] E. REKANOVIĆ I P M Mihajlović. In vitro sensitivity of Fusarium graminearum (Schwabe) to difenoconazole, prothioconazole and thiophanate-methyl[J]. Pesticidi I Fitomedicina, 2010, 25 1: 325-333. DOI:
10.2298/pif1004325r[5] L. L. VAWDREY D. W K R E Grice. Field and laboratory evaluations of fungicides for the control of brown spot (Corynespora cassiicola) and black spot (Asperisporium caricae) of papaya in far north Queensland, Australia[C]//37 6. 2008: 552-558. DOI:
10.1071/ap08055
