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BocNH-PEG5-acid

BocNH-PEG5-acid Property

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BocNH-PEG5-acid Chemical Properties,Usage,Production

Description t-Boc-N-amido-PEG5-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^? molecules) for targeted protein degradation.
reaction suitability reaction type: Pegylations
reagent type: cross-linking reagent
IC 50 PEGs

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BocNH-PEG5-acid Spectrum

890152-41-7, BocNH-PEG5-acidRelated Search:

peg
高端化学
助剂
PEG类产品-Boc-PEG
C17H33NO9
2,2-二甲基-4-氧代-3,8,11,14,17,20-六氧杂-5-氮杂二十二烷-22-酸
T-BOC-N-AMIDO-PEG5-ACETIC ACID;≥98%
17-{[(叔丁氧基)羰基]氨基}-3,6,9,12,15-五氧杂十七烷酸
17-(BOC-氨基)-3,6,9,12,15-五氧杂十七烷-1-甲酸
叔丁氧羰基氨基-五聚乙二醇-乙酸
氨基叔丁酯-五聚乙二醇-乙酸
叔丁氧羰基-PEG5-乙酸
叔丁氧羰基五聚乙二醇乙酸
BOCNH-PEG5酸
890152-41-7
2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid
17-{[(tert-butoxy)carbonyl]amino}-3,6,9,12,15-pentaoxaheptadecanoic acid
2-[2-[2-[2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
17-(Boc-amino)-3,6,9,12,15-pentaoxaheptadecan-1-oic Acid
BocNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(1,1-dimethylethyl) ester
NHBoc-PEG5-CH2COOH
T-boc-n-amido-peg5-ch2co2h
BocNH-P5-CH2CO2H
t-boc-N-amido-PEG5-acetic acid
5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(1,1-dimethylethyl) ester
BocNH-PEG5-acid