Chemical Properties
colourless liquid
Uses
Trifluoroacetaldehyde monohydrate is used as an agricultural
chemical, a drug and therapeutic agent, a fungicide, bactericide,
and wood preservative.
Uses
One general application of trifluoroacetaldehyde is the preparation of trifluoroethylamino derivatives via reductive amination reaction. This synthesis includes the formation of the corresponding N,O-acetal intermediates followed by their reduction using NaBH4or 2-picoline borane complex, affording the target trifluoroethylamino compounds in moderate to good yields. Another general application of trifluoroacetaldehyde is the synthesis of chiral α-substituted trifluoroethylamino compounds.
Safety Profile
Moderately toxic by ingestion,intravenous, and intraperitoneal routes. When heated todecomposition it emits very toxic fumes of F.
Synthesis
Raw materials with components of 1,1,1-trifluoroethane, oxygen, and nitrogen were mixed and preheated at a molar ratio of 1:1.5:1~10 and then injected into a fixed-bed reactor, and reacted with 2%~16% Fe2O3/AlF3 or 2%~16% CuO/AlF3 as a catalyst at 0.1~2 MPa and 200~400C. The reaction was carried out continuously, and the exported product was absorbed with water and trifluoroacetaldehyde hydrate was isolated.
