ChemicalBook Product Catalog Organic Chemistry Organic fluorine compound D-AMETHOPTERIN HYDRATE, 95

D-AMETHOPTERIN HYDRATE, 95

Product NameD-AMETHOPTERIN HYDRATE, 95
CAS6745-93-3
CBNumberCB0499006
MFC20H22N8O5.H2O
MW472.46
EINECS257-482-2
MDL NumberMFCD00006710
MOL File6745-93-3.mol

Chemical Properties

Melting point:

195 °C (dec.)(lit.)

Safety

Hazard Codes	T
Risk Statements	46-60-61-25-36/37/38
Safety Statements	53-22-26-36/37/39-45
RIDADR	UN 1544 6.1/PG 3
RTECS	MA1224000
Toxicity	LD50 i.v. in rats: 14 mg/kg (Scherf)

D-AMETHOPTERIN HYDRATE, 95 Chemical Properties,Usage,Production

Uses

Methotrexate (Amethopterin) monohydrate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate monohydrate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

Definition

ChEBI: Methotrexate hydrate is a member of folic acids.

in vivo

Methotrexate (Amethopterin) monohydrate reduces thymus and spleen indices of mice. Methotrexate monohydrate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate monohydrate exposure on indices of thymus and spleens in mice^[2].
Methotrexate (MTX) monohydrate (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate monohydrate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity^[4].

IC 50

Traditional Cytotoxic Agents

References

[1] Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73. PMID:17922664
[2] Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. PMID:16963793
[3] Ehab Tousson, et al. The Effect of L-carnitine on Amethopterin-induced Toxicity in Rat Large Intestine.
[4] Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550. DOI:10.4103/0253-7613.84970

D-AMETHOPTERIN HYDRATE, 95 Suppliers

Supplier	Tel	Email	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	32430	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	19950	58
CHG Opto-Electronic Corporation Limited	2537653158 16621191650	2537653158@qq.com	7083	58
Abcam Limited	021-2070050 400921018	us.orders@abcam.com	6000	50
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	24951	58
Enzo Biochem Inc	Enzo Biochem Inc. 13797054060	Enzoname@qq.com	6173	58
Biosynth Biological Technology (Suzhou) Co Ltd	51288865780	sales@biosynth.com	6031	58
Service Chemical Inc.	888-895-6920	sales@chemos-group.com	6281	71
SIGMA-RBI	800 736 3690 (Orders)		6825	91
Riedel-de Haen AG	800 558-9160		6624	87

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