Uses
FLT3LG (Fms-related tyrosine kinase 3 ligand) is a transmembrane glycoprotein and a ligand for FLT3 receptor.
It is widely expressed in human tissues. The protein exists in membrane bound as well as secreted forms.
Binding of FLT3LG to FLT3 results in receptor dimerization, activation of the tyrosine kinase domain, autophosphorylation and thereby activation of the receptor.
Recombinant human Flt3-Ligand is a soluble 17.6kDa protein consisting of 155 amino acid residues.
Biological Activity
FLT3LG (Fms-related tyrosine kinase 3 ligand) is a hematopoietic growth factor. It plays a significant role in the development of myeloid and plasmacytoid dendritic cells. It is also involved in the expansion of Treg (T regulatory) cells, thereby offering treatment for autoimmune disorders and transplantation processes. FLT3LG is associated with autoimmune arthritis, for instance rheumatoid arthritis and primary Sjogrenμs syndrome. FLT3LG along with FLT3 is involved in the proliferation of primary AML (acute myeloid leukemia) blasts and autocrine signaling in AML.
Description
Flt3-Ligand Human Recombinant produced in E.Coli is a non-glycosylated, polypeptide chain containing 155 amino acids and having a molecular mass of approximately 17.6kDa.
Flt3-Ligand is purified by proprietary chromatographic techniques.
Background
FLT3 ligand is a receptor for the fl cytokine has a tyrosine-protein kinase activity & a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand synergizes with other CSFs and interleukins to induce growth and differentiation.
