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DL-THIORPHAN

DL-THIORPHAN Structure
DL-THIORPHAN
  • CAS No.76721-89-6
  • Chemical Name:DL-THIORPHAN
  • CBNumber:CB0479626
  • Molecular Formula:C12H15NO3S
  • Formula Weight:253.32
  • MOL File:76721-89-6.mol
DL-THIORPHAN Property
  • Melting point 138-140 °C
  • Boiling point 524.0±50.0 °C(Predicted)
  • Density 1.246±0.06 g/cm3(Predicted)
  • RTECS MC0596440
  • storage temp. -15°C
  • solubility ethanol: 50 mg/mL, clear, colorless
  • form White solid
  • pka 3.48±0.10(Predicted)
  • color White to Off-White
  • BRN 4872101
  • CAS DataBase Reference 76721-89-6
  • FDA UNII B79L7B5X3Z
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
  • F  :10
  • HS Code  :29309090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
DL-THIORPHAN Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: T6031
  • Product name : DL-Thiorphan
  • Purity: ≥98% (TLC)
  • Packaging: 5MG
  • Price: ₹17991.15
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T6031
  • Product name : DL-Thiorphan
  • Purity: ≥98% (TLC)
  • Packaging: 25MG
  • Price: ₹71369.23
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 598510
  • Product name : DL-Thiorphan - CAS 76721-89-6 - Calbiochem
  • Purity: A thiol containing amido-acid that selectively binds to the active site zinc of metalloproteinases and blocks their activity (IC?? = 2.1 nM for neutra
  • Packaging: 10MG
  • Price: ₹39430
  • Updated: 2022/06/14
  • Buy: Buy

DL-THIORPHAN Chemical Properties,Usage,Production

  • Chemical Properties Off-White Solid
  • Uses Thiorphan is a potent inhibitor of neprilysin, a membrane metallo-endopeptidase that cleaves peptide hormones, such as enkephalins, glucagon, and bradykinin (Ki = 4-140 nM). It is much less effective against neprilysin-2 (IC50 = 22.1 μM), angiotensin-converting enzyme, and endothelin-converting enzyme-1. Thiorphan can be produced in vivo via the metabolism of the prodrug acetorphan. Neprilysin is overexpressed in many forms of cancer and may play a role in protecting against Alzheimer’s disease.
  • Uses An Enkephalinase inhibitor
  • Uses DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.
  • Uses The active metabolite
  • Definition ChEBI: Thiorphan is a N-acyl-amino acid.
  • General Description A thiol-containing amido-acid that selectively binds to the active site zinc of neprilysin (also known as neutral endopeptidase and NEP) and inhibits its activity (IC50 = 2.1 nM). Inhibits the β-amyloid (Aβ) degrading activity of neprilysin in vivo, but does not affect the secretion of either Aβ peptide or amyloid precursor protein (APP). Also shown to inhibit other neprilysin-related family members, such as mouse NL1 (IC50 = 47 nM) and the neprilysin homolog from Ascaris suum (IC50 = 22 μM). Inhibits the activity of angiotensin-converting enzyme (ACE) (IC50 = 140 nM), but has no effect on the activity of endothelin-converting enzyme (ECE).
  • Biochem/physiol Actions Primary TargetNEP activity
DL-THIORPHAN Preparation Products And Raw materials
Raw materials
Preparation Products
DL-THIORPHAN Suppliers
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DL-THIORPHAN Spectrum
76721-89-6, DL-THIORPHANRelated Search:
  • Sulfur & Selenium Compounds
  • Inhibitors
  • Amino Acids & Derivatives
  • Amino Acids 13C, 2H, 15N
  • Aromatics
  • 化学试剂
  • 抑制剂
  • 杂质对照品
  • 350-消旋卡多曲
  • 标准品
  • D to K
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Type
  • Enzyme Inhibitors by Enzyme
  • Organic Covalent Modifiers
  • Biochemicals and Reagents
  • BioChemical
  • Enkephalinase
  • Enzyme Inhibitors
  • 25332
  • 消旋卡多曲21B
  • 3-巯基-2苄基丙基甘氨酸,10 MM DMSO 溶液
  • THIORPHAN,NEPRILYSIN/NEUTRAL ENDOPEPTIDASE抑制剂
  • 消旋卡多曲杂质16
  • 噻啡
  • 2-(2-苄基-3-巯基丙酰氨基)乙酸
  • 消旋卡多曲杂质2(消旋卡多曲EP杂质B)
  • DL-噻奥芬
  • 2H7]-D,L-噻奥芬
  • 塞奥芬-D5
  • 消旋卡多曲21
  • 消旋卡多曲用杂质B
  • 2-(2-苄基-3-巯基丙酰胺基)乙酸
  • DL-噻吩
  • DL-四氢噻吩
  • 塞奥芬
  • 甘氨酸-D5
  • 3-巯基-2苄基丙基甘氨酸
  • 2-巯基甲基-(3-苯基丙酰基氨基)-乙酸
  • 2-[[2-(苄基)-3-硫基丙酰]氨基]乙酸
  • 76721-89-6
  • <sc>DL</sc>-Thiorphan
  • Thiorphan, 10 mM in DMSO
  • Thiorphan/S-[2-(2-Bromo-3-methoxyphenyl)-2-oxoethyl] Thiorphan Dicyclohexylamine Salt
  • Thiorphan, Neprilysin/neutral endopeptidase inhibitor
  • [[(2RS)-2-benzyl-3-sulfanylpropanoyl]amino]acetic acid
  • (2-benzyl-3-mercaptopropanoyl)glycine
  • DL-THIORPHAN USP/EP/BP
  • 2-[(2-benzyl-3-sulfanylpropanoyl)amino]aceticaci
  • Glycine, N-[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-
  • Racecadotril impurity 1/Racecadotril EP impurity B/Thiorphan/[[(2RS)-2-benzyl-3-sulfanylpropanoyl]amino]acetic acid
  • 2-(2-benzyl-3-sulfanylpropanamido)acetic acid
  • Racecadotril Impurity 2（Racecadotril EP Impurity B）
  • DL-Thiorphan - CAS 76721-89-6 - Calbiochem
  • DL-THIORPHAN
  • (DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLY-OH
  • DL-3-MERCAPTO-2-BENZYLPROPANOYL-GLYCINE
  • (DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLY

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