Substance P (6-11)
- Product NameSubstance P (6-11)
- CAS51165-07-2
- CBNumberCB0417745
- MFC36H52N8O7S
- MW740.91
- MDL NumberMFCD00076797
- MOL File51165-07-2.mol
Chemical Properties
| Boiling point: | 1198.894±65.00 °C(Press: 760.00 Torr)(predicted) |
| Density | 1.240±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | -15°C |
| pka | 13.332±0.46(predicted) |
Substance P (6-11) Chemical Properties,Usage,Production
Uses
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].in vivo
Substance P (6-11) (0.1-10 nM) inhibits insulin and glucagon secretion from the rat pancreas in a dose-dependent manner. In the canine pancreas, by contrast, Substance P (6-11) (1-10 nM), potentiates the release of insulin, glucagon, and somatostatin[2].
References
[1] Y Torrens, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51. DOI:10.1016/s0143-4179(97)90055-x[2] Y Chiba, et al. Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117(5):1996-2000. DOI:10.1210/endo-117-5-1996
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51165-07-2(Substance P (6-11)) Related Search
- SUBSTANCE P
- Substance P (1-7)
- Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 3AcOH 5H2O
- substance P (3-11)
- (LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT)
- Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA
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- NEUROPEPTIDE F
- GALANIN, PORCINE
- NEUROPEPTIDE FF
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