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Aceclofenac

Description Mechanism of Action Precautions

Aceclofenac

CAS No.89796-99-6
Chemical Name:Aceclofenac
CBNumber:CB0402570
Molecular Formula:C16H13Cl2NO4
Formula Weight:354.18
MOL File:89796-99-6.mol

Aceclofenac Property

Melting point 149-153°C
Boiling point 486.0±45.0 °C(Predicted)
Density 1.455±0.06 g/cm3(Predicted)
RTECS CY1577900
storage temp. 2-8°C
solubility Soluble in DMSO
form powder
pka 2.60±0.10(Predicted)
color off-white to light tan
Water Solubility 32mg/L(32 ºC)
Merck 14,22
InChIKey MNIPYSSQXLZQLJ-UHFFFAOYSA-N
CAS DataBase Reference 89796-99-6(CAS DataBase Reference)
FDA UNII RPK779R03H
ATC code M01AB16,M02AA25
EPA Substance Registry System Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, carboxymethyl ester (89796-99-6)
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :T,N
Risk Statements :25-36-50/53
Safety Statements :26-45-60-61
RIDADR :UN 2811 6.1 / PGIII
WGK Germany :3
HazardClass :6.1
PackingGroup :III
HS Code :29224999

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H301-H319-H410
Precautionary statements P273-P301+P310+P330-P305+P351+P338

Aceclofenac Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: A8861
Product name : Aceclofenac
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: ₹8746.6
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: PHR3166
Product name : Aceclofenac
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 100MG
Price: ₹61605.08
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: A8861
Product name : Aceclofenac
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: ₹35744.15
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: A2484
Product name : Aceclofenac
Purity:
Packaging: 1G
Price: ₹2200
Updated: 2022/05/26
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Brand: TCI Chemicals (India)
Product number: A2484
Product name : Aceclofenac
Purity:
Packaging: 5G
Price: ₹5200
Updated: 2022/05/26
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Aceclofenac Chemical Properties,Usage,Production

Description Aceclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) that is commonly prescribed for people with painful rheumatic conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
The drug should not be given to children, breastfeeding mothers, and people with porphyria. Pregnant women should not also be given aceclofenac as they risk developing patent ductus arteriosus in the neonate.
Mechanism of Action Aceclofenac acts by inhibiting the effect of natural substances known as cyclooxygenase (COX) enzymes. Notably, these enzymes are responsible for making other chemicals in the body, namely prostaglandins. The prostaglandins are normally produced at sites of damages or injury cause inflammation and pain. By blocking the influence of COX enzymes, production of prostaglandins is minimized, meaning that the swelling and pain is eased.
Precautions Before taking aceclofenac, it is essential to tell the doctor if one has ever had an allergic reaction to any other NSAID, for instance, diclofenac, aspirin, indomethacin, and naproxen; whether one has allergic disorders such as asthma. It is important to alert the doctor if an individual has a heart condition or problem with circulation or blood vessels. Moreover, inform the physician if one has connective tissue disorder, for instance, lupus erythematosus. One should not take the drug if he/she has high blood pressure or has blood-clotting problems.
Description Aceclofenac is a nonsteroidal antiinflammatory agent with analgesic and antipyretic properties. It is reported to be useful in the treatment of osteoarthritis, rheumatoid arthritis and pain associated with minor surgical procedures. Compared to ketoprofen in the treatment of rheumatoid arthritis, aceclofenac is substantially faster acting.
Chemical Properties White Crystalline Solid
Originator Prodes (Prodesfarma) (Spain)
Uses Aceclofenac is a non-steroidal, anti-inflammatory drug (NSAID) with potent inhibitory activity in several models of inflammation. It is used for the treatment of osteoarthritis and rheumatoid arthritis. It is a Biopharmaceutics classification system class II (BCS class I) drug which has an intermediate half-life of 3-4h and undergoes substantial first pass metabolism. aceclofenac is available either in oral form (tablet) or in topical form (gel).
Uses Labeled Aceclofenac, intended for use as an internal standard for the quantification of Aceclofenac by GC- or LC-mass spectrometry.
Definition ChEBI: Aceclofenac is a monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a monocarboxylic acid, a carboxylic ester, a secondary amino compound, an amino acid and a dichlorobenzene. It derives from a diclofenac.
brand name Airtal; Gerbin
Therapeutic Function Analgesic, Antiinflammatory
Biochem/physiol Actions Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.
Clinical Use NSAID and analgesic
Drug interactions Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists: antagonism of hypotensive effect; increased risk of nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more NSAIDs, including aspirin (increased side effects); avoid with ketorolac (increased risk of side effects and haemorrhage).
Antibacterials: possible increased risk of convulsions with quinolones.
Anticoagulants: effects of coumarins and phenindione enhanced; possibly increased risk of bleeding with heparins, dabigatran and edoxaban - avoid long term use with edoxaban.
Antidepressants: increased risk of bleeding with SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas enhanced.
Antiepileptics: possibly increased phenytoin concentration.
Antivirals: increased risk of haematological toxicity with zidovudine; concentration possibly increased by ritonavir.
Ciclosporin: may potentiate nephrotoxicity
Cytotoxics: reduced excretion of methotrexate; increased risk of bleeding with erlotinib.
Diuretics: increased risk of nephrotoxicity; antagonism of diuretic effect, hyperkalaemia with potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity.
Metabolism About two-thirds of a dose is excreted in the urine, mainly as hydroxymetabolites, the principal one being 4-hydroxyaceclofenac. A small amount is converted to diclofenac.