Gigavlkvlttglpaliswikrkrq-OH
- Product NameGigavlkvlttglpaliswikrkrq-OH
- CAS123168-46-7
- CBNumberCB0401937
- MFC131H228N38O32
- MW2847.45
- MDL NumberMFCD00080195
- MOL FileMol file
Gigavlkvlttglpaliswikrkrq-OH Chemical Properties,Usage,Production
Uses
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2].in vivo
Melittin (intraperitoneal inoculation) increases 13,14-dihydro-15-keto-PGE2 levels in peripheral blood of mice[1].
References
[1] Hassid A, Levine L. Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo. Res Commun Chem Pathol Pharmacol. 1977. PMID:928951[2] Memariani H, Memariani M. Anti-fungal properties and mechanisms of melittin. Appl Microbiol Biotechnol. 2020 Aug;104(15):6513-6526. DOI:10.1007/s00253-020-10701-0
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