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TPCK

TPCK Structure
TPCK
  • CAS No.402-71-1
  • Chemical Name:TPCK
  • CBNumber:CB0354828
  • Molecular Formula:C17H18ClNO3S
  • Formula Weight:351.85
  • MOL File:402-71-1.mol
TPCK Property
  • Melting point 106-108 °C(lit.)
  • Boiling point 509.9±60.0 °C(Predicted)
  • Density 1.1350 (rough estimate)
  • refractive index 1.6100 (estimate)
  • storage temp. -20°C
  • solubility DMSO: >10 mg/mL stable for several months at 4°C.
  • form powder
  • pka 8.71±0.50(Predicted)
  • color white
  • biological source synthetic
  • BRN 2895215
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
  • CAS DataBase Reference 402-71-1
  • FDA UNII P598716LJT
  • EPA Substance Registry System Benzenesulfonamide, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-4-methyl- (402-71-1)
  • UNSPSC Code 12352202
  • NACRES NA.77
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :37/38-41
  • Safety Statements  :26-36
  • RIDADR  :UN 3335
  • WGK Germany  :3
  • RTECS  :XT5613500
  • F  :10-19-21
  • TSCA  :Yes
  • HS Code  :29350090
  • NFPA 704:
    0
    3 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H315-H318-H335
  • Precautionary statements P280-P302+P352-P305+P351+P338+P310
TPCK Price More Price(5)
  • Brand: Sigma-Aldrich(India)
  • Product number: T4376
  • Product name : N-p-Tosyl-L-phenylalanine chloromethyl ketone
  • Purity: ≥97% (TLC), powder
  • Packaging: 100MG
  • Price: ₹3723.8
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T4376
  • Product name : N-p-Tosyl-L-phenylalanine chloromethyl ketone
  • Purity: ≥97% (TLC), powder
  • Packaging: 250MG
  • Price: ₹7328.53
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T4376
  • Product name : N-p-Tosyl-L-phenylalanine chloromethyl ketone
  • Purity: ≥97% (TLC), powder
  • Packaging: 1G
  • Price: ₹18478.28
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: T4376
  • Product name : N-p-Tosyl-L-phenylalanine chloromethyl ketone
  • Purity: ≥97% (TLC), powder
  • Packaging: 5G
  • Price: ₹73122.88
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 616387
  • Product name : Nα-Tosyl-Phe Chloromethyl Ketone
  • Purity: Irreversible inhibitor of chymotrypsin.
  • Packaging: 250MG
  • Price: ₹5880
  • Updated: 2022/06/14
  • Buy: Buy

TPCK Chemical Properties,Usage,Production

  • Description TPCK (402-71-1) is an irreversible inhibitor of the serine protease chymotrypsin.1 It also inhibits certain cysteine proteases (bromelain, ficin, papain).1 TPCK inhibited (IC50 = 5 μM) the mitogen-induced activation of pp70s6k, a mitogen-regulated serine/threonine kinase involved in the G1 to S phase transition of the cell cycle.2
  • Chemical Properties white crystalline powder
  • Uses N-α-Tosyl-L-phenylalanylchloromethane is a proteinase inhibitors with apoptotic function. Studies have shown that it induces caspase-dependent apoptosis in Epstein-Barr virus (EBV)-transformed human B cell lines with release of pro-apoptotic proteins from mitochondria. It also results in down-regulation of the anti-apoptotic proteins and caspase-dependent cleavage of two anti-apoptotic proteins. It promotes dephosphorylation of p53 on serine residues.
  • Definition ChEBI: The N-tosyl derivative of L-phenylalanyl chloromethyl ketone.
  • Biochem/physiol Actions Blocks the LPS- or cytokine-induced activation of nuclear factor κB (NFκB), which, in turn, blocks the induction of iNOS and COX-2 transcription. Blocks activation of pp70s6k by all mitogens. Blocks apoptosis cell lines by inhibiting the processing of caspases in some cell lines and to some stimuli. Also blocks apoptosis initiated by Taxol (in MCF-7 human breast carcinoma cells).
  • Safety Profile Experimental reproductive effects. A flammable liquid. When heated to decomposition it emits toxic fumes of NOx, SOx, and Cl-.
  • References 1) Bond and Butler, (1987) Intracellular proteases; Annu. Rev. Biochem., 56 333 2) Grammer and Blenis (1996) The serine protease inhibitors, tosylphenylalanine chloromethylketone and tosyllysine chloromethylketone, potently inhibit pp70s6k activation; J. Biol. Chem., 271 23650
TPCK Preparation Products And Raw materials
Raw materials
Preparation Products
TPCK Suppliers
Global(145)Suppliers
  • Supplier：
    career henan chemical co
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    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
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  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
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  • Advantage：58
  • Supplier：
    Nextpeptide Inc
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  • Email：sales@nextpeptide.com
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  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
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  • Advantage：58
  • Supplier：
    GIHI CHEMICALS CO.,LIMITED
  • Tel： +8618058761490
  • Email：info@gihichemicals.com
  • Country：China
  • ProdList：49984
  • Advantage：58
  • Supplier：
    LEAPCHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：43340
  • Advantage：58
TPCK Spectrum
402-71-1, TPCKRelated Search:
  • Apoptosis Inhibitors
  • 抑制剂
  • 生化试剂
  • 通用生化试剂-氨基酸
  • 化工原料
  • 生化试剂-氨基酸类
  • 中药对照品
  • 细胞信号和神经生物学
  • 氨基酸类
  • 细胞裂解蛋白酶抑制剂
  • 蛋白酶抑制剂
  • 氨基酸
  • 细胞生物学
  • Biochemicals and Reagents
  • BioChemical
  • A to C
  • Chymotrypsin, alpha-
  • Enzyme Inhibitors by Type
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Organic Covalent Modifiers
  • C6H5CH2CHNHSO2C6H4CH3COCH2Cl
  • C17H18ClNO3S
  • L-1,4'-甲基磺酰基-2-苯基乙基氯甲基酮,10 MM DMSO 溶液
  • TPCK,CHYMOTRYPSIN AND SMASE抑制剂
  • L-1-TOSYLAMIDO-2-PHENYLETHYL CHLOROMETHYL KETONE; L-TPCK
  • (S)-N-(4-氯-3-氧代-1-苯基丁烷-2-基)-4-甲基苯磺酰胺
  • N-[(1S)-3-氯-2-氧代-1-(苯基甲基)丙基]-4-甲基-苯磺酰胺
  • N-对甲苯磺酰基-L-苯丙氨酸氯甲基酮
  • N-对-甲苯磺酰基-L-苯基乙基氯甲基酮
  • N-(P-TOLUENESULFONYL)-L-PHENYLALANYL CHLOROMETHYL KETONE N-(对甲苯磺酰基)-L-苯丙氨酰甲基氯酮
  • (S)-1-氯-4-苯基-3-磺酰氨基-2-丁酮
  • (S)-1-氯-3-磺酰胺基-4-苯基-2-丁酮
  • L-1,4'-甲基磺酰基-2-苯基乙基氯甲基酮
  • NA-对甲苯磺酰-L-苯丙氨酸氯甲基酮
  • N-(对甲苯磺酰基)-L-苯丙氨酰甲基氯酮(TPCK)
  • TPCK(进分)
  • 甲苯磺酰基-L-氨基联苯氯甲基酮
  • N-ALPHA-对甲苯磺酰基-L-苯丙氨酰氯甲烷
  • N-(对甲苯磺酰基)-L-苯丙氨酰甲基氯酮
  • 甲苯磺酰基-L-氨基联苯氯甲基酮(TPCK)
  • 402-71-1
  • N-<i>p</i>-Tosyl-<sc>L</sc>-phenylalanine chloromethyl ketone
  • N<sup>α</sup>-Tosyl-Phe Chloromethyl Ketone
  • TPCK, 10 mM in DMSO
  • TPCK, chymotrypsin and SMase inhibitor
  • L-TPCK
  • N-(p-Toluenesulfonyl)-L-phenylalanylchloromethane
  • N-[(1S)-3-Chloro-2-Oxo-1-(Phenylmethyl)Propyl]-4-Methyl-Benzenesulfonamide
  • (S)-N-(4-Chloro-3-oxo-1-phenyl-2-butyl)-p-toluenesulfonamide
  • TPCK USP/EP/BP
  • N-a-Tosyl-L-phenylalanylchloromethane
  • N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide
  • n-2-p-Tosyl-L-phenylalanine-chlorometjylketone
  • (S)-N-(4-Chloro-3-oxo-1-phenylbutan-2-yl)-4-methylbenzenesulfonamide
  • (S)-1-Chloro-3-tosylamido-4-phenyl-2-butanone, (S)-1-Chloro-4-phenyl-3-tosylamido-2-butanone, N-p-Tosyl-L-phenylalanine chloromethyl ketone, Tosyl-L-phenylalanyl-chloromethane, TPCK
  • TOSYL-L-PHENYLALANINE-CHLOROMETHYL KETONE (TPCK)

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