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DICHLORISONE ACETATE

DICHLORISONE ACETATE Structure
DICHLORISONE ACETATE
  • CAS No.79-61-8
  • Chemical Name:DICHLORISONE ACETATE
  • CBNumber:CB0339584
  • Molecular Formula:C23H28Cl2O5
  • Formula Weight:455.37
  • MOL File:79-61-8.mol
DICHLORISONE ACETATE Property
  • Melting point 246-253 °C (decomp)
  • alpha D25 +162° (dioxane)
  • Boiling point 596.2±50.0 °C(Predicted)
  • Density 1.34±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • solubility DMSO: 4.35 mg/mL (9.55 mM); Water: < 0.1 mg/mL (insoluble)
  • pka 11.94±0.70(Predicted)
  • form Solid
  • color White to off-white
  • FDA UNII 64FTA4579H
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

DICHLORISONE ACETATE Chemical Properties,Usage,Production

  • Originator Diloderm ,Schering,US,1960
  • Uses antipruretic
  • Definition ChEBI: Dichlorisone is a corticosteroid hormone.
  • Manufacturing Process A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21- acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
    with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture is stirred for 2 hours and poured into ice water. The crude product is filtered and washed with water to give 1.12 g of solid material, which is recrystallized from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4- pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).
  • brand name Diloderm (Schering).
  • Therapeutic Function Antipruritic, Antihistaminic, Appetite stimulant
DICHLORISONE ACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
DICHLORISONE ACETATE Suppliers
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DICHLORISONE ACETATE Spectrum
79-61-8, DICHLORISONE ACETATERelated Search:
  • DILODERM
  • Inhibitors
  • 抑制剂
  • 小分子抑制剂，天然产物
  • 小分子抑制剂
  • C23H28Cl2O5
  • 醋酸二氯松,10 MM DMSO 溶液
  • 糊状叶绿素,DILODERM,醋酸二氯松
  • 醋酸二氯松
  • 79-61-8
  • Dichlorisone Acetate, 10 mM in DMSO
  • 1, 4-PREGNADIEN-9α, 11β-DICHLORO-17, 21-DIOL-3, 20-DIONE 21-ACETATE
  • inhibit,Inhibitor,Dichlorisone,Endogenous Metabolite,Dichlorisone Acetate
  • Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11b)-
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9,11-dichloro-17-hydroxy-, (11β)-
  • DICHLORISONE ACETATE
  • acetic acid [2-[(9R,17R)-9,11-dichloro-17-hydroxy-3-keto-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-keto-ethyl] ester
  • [2-[(9R,17R)-9,11-dichloro-17-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] ethanoate
  • [2-[(9R,17R)-9,11-dichloro-17-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
  • Sch 5005
  • 21-Acetyloxy-9,11β-dichloro-17-hydroxypregna-1,4-diene-3,20-dione
  • 9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate
  • dichlorisone 21-acetate
  • 1,4-PREGNADIEN-9-ALPHA, 11-BETA-DICHLORO-17,21-DIOL-3,20-DIONE 21-ACETATE
  • 9ALPHA,11BETA-DICHLORO-17ALPHA,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE

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