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BI 1744 hydrochloride

BI 1744 hydrochloride Structure
BI 1744 hydrochloride
  • CAS No.869477-96-3
  • Chemical Name:BI 1744 hydrochloride
  • CBNumber:CB03052079
  • Molecular Formula:C21H27ClN2O5
  • Formula Weight:422.90248
  • MOL File:869477-96-3.mol
BI 1744 hydrochloride Property
  • Melting point 153-155°C
  • storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • color Off-White to Pale Beige
  • Water Solubility Water : 250 mg/mL (591.16 mM; Need ultrasonic)
  • Stability Hygroscopic
  • FDA UNII 65R445W3V9
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H319-H361-H302-H372
  • Precautionary statements P264-P280-P305+P351+P338-P337+P313P-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P260-P264-P270-P314-P501

BI 1744 hydrochloride Chemical Properties,Usage,Production

  • Description Olodaterol hydrochloride was approved for long-term, oncedaily maintenance treatment of chronic obstructive pulmonary disease (COPD) in 2013 in the following countries: Canada, Russia, United Kingdom, Denmark, and Iceland. The drug has been recommended by a federal advisory panel for approval by the FDA. Developed and marketed by Boehringer Ingelheim, olodaterol is a long-acting b2-adrenergic receptor agonist with high selectivity over the b1- and b3-receptors (219- and 1622-fold, respectively). Upon binding to and activating the b2-adrenergic receptor in the airway, olodaterol stimulates adenyl cyclase to synthesize cAMP, leading to the relaxation of smooth muscle cells in the airway. Administered by inhalation using the Respimat® Soft Mist inhaler, it delivers significant bronchodilator effects within five minutes of the first dose and provides sustained improvement in forced expiratory volume (FEV1) for over 24 h.
  • Uses Olodaterol is a long acting β-adrenoceptor agonist used as an inhalation for treating patients with chronic obstructive pulmonary disease (COPD).
  • Definition ChEBI: A hydrochloride obtained by combining olodaterol with one equivalent of hydrochloric acid. Used for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.
  • Synthesis Commercial 20,50-dihydroxyacetophenone (122) was treated with one equivalent of benzyl bromide and potassium carbonate in methylisobutylketone (MIBK) to give the 50-monobenzylated product in 76% yield. Subsequent nitration occurred at the 40-position to provide nitrophenol 123 in 87% yield. Reduction of the nitro group followed by subjection to chloroacetyl chloride resulted in the construction of benzoxazine 124 in 82% yield. Next, monobromination through the use of tetrabutylammonium tribromide occurred at the acetophenone carbon to provide bromoketone 125, and this was followed by asymmetric reduction of the ketone employing ()-DIP chloride to afford an intermediate bromohydrin, which underwent conversion to the corresponding epoxide 126 in situ upon treatment with aqueous NaOH. This epoxide was efficiently formed in 85% yield and 98.3% enantiomeric excess. Epoxide 126 underwent ring-opening upon subjection to amine 127 to provide amino-alcohol 128 in in 84¨C90% yield and 89.5¨C99.5% enantiomeric purity following salt formation with HCl. Tertiary amine 127 was itself prepared in three steps by reaction of ketone 129 with methylmagnesium chloride, Ritter reaction of the tertiary alcohol with acetonitrile, and hydrolysis of the resultant acetamide with ethanolic potassium hydroxide. Hydrogenative removal of the benzyl ether within 128 followed by recrystallization with methanolic isopropanol furnished olodaterol hydrochloride (XVI) in 63¨C70% yield. Overall, the synthesis of olodaterol hydrochloride required 10 total steps (7 linear) from commercially available acetophenone 122.

    Synthesis_869477-96-3

  • in vivo

    Olodaterol (1 mg/kg; inhal.; 21 days) accelerats body weights recovery back to control levels (at day 21) and attenuats TGF-β-induced lung fibrosis[2].
    Olodaterol (0.1~3 μg/kg; inhal.; 5 hours) induces a dose-dependent bronchoprotection[3].
    Olodaterol (0.3 and 0.6 μg/kg; inhal.; 24 hours) induces a maximal bronchoprotection of approximately 60 % after 0.5 hours[3].

    Animal Model:Lung fibrosis C57BL/6 mice
    Dosage:1 mg/mL
    Administration:Inhal.; 21 days
    Result:Accelerated body weight recovery back to control levels (at day 21) and attenuated TGF-β-induced lung fibrosis.
    Animal Model:Guinea Pigs
    Dosage:0.1~3 μg/kg
    Administration:Inhal.; 5 hours
    Result:Induced a dose-dependent bronchoprotection.
    Animal Model:Dogs
    Dosage:0.3 and 0.6 μg/kg
    Administration:Inhal.; 24 hours
    Result:Olodaterol (0.6 μg/kg) induced a maximal bronchoprotection of approximately 60 % after 0.5 h.
  • IC 50 β2 adrenoceptor: .1 nM (EC50)
BI 1744 hydrochloride Preparation Products And Raw materials
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BI 1744 hydrochloride Spectrum
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