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HNE

HNE Structure
HNE
  • CAS No.75899-68-2
  • Chemical Name:HNE
  • CBNumber:CB0281140
  • Molecular Formula:C9H16O2
  • Formula Weight:156.22
  • MOL File:75899-68-2.mol
HNE Property
  • Boiling point 125-127 °C(Press: 2 Torr)
  • Density 0.941±0.06 g/cm3(Predicted)
  • storage temp. -70°C
  • solubility DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >1 mg/ml
  • pka 13.31±0.20(Predicted)
  • form Colorless oil.
  • color Colorless to light yellow
  • CAS DataBase Reference 75899-68-2(CAS DataBase Reference)
  • FDA UNII K1CVM13F96
  • UNSPSC Code 12352114
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H225-H319
  • Precautionary statements P210-P233-P240-P241-P242-P305+P351+P338
HNE Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 393204
  • Product name : 4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem
  • Purity: 4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific mar
  • Packaging: 1MG
  • Price: ₹13100
  • Updated: 2022/06/14
  • Buy: Buy

HNE Chemical Properties,Usage,Production

  • Uses 4-Hydroxynonenal is an irreversible inhibitor of Na+/K+-ATPase activity.
  • Uses HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid. 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 μM.[Cayman Chemical]
  • Definition ChEBI: 4-hydroxynon-2-enal is an enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position. It has a role as a human metabolite. It is a hydroxyaldehyde, an enal and a 4-hydroxynonenal.
  • Biological Activity Primary Target
    Na+, K+-ATPase activity', 'Product does not compete with ATP.', 'Target IC50: 120 μM against Na+, K+-ATPase activity
  • in vivo

    Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2+/+) and Nrf2-deficient mice (Nrf2-/-) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2+/+ and Nrf2-/- mice. Similar to iNOS result, in Nrf2-/- KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2+/+ WT animals[2].

  • IC 50 ALDH2; Human Endogenous Metabolite
HNE Preparation Products And Raw materials
Raw materials
Preparation Products
HNE Suppliers
Global(123)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
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  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：marketing@targetmol.com
  • Country：United States
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  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
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  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
HNE Spectrum
75899-68-2, HNERelated Search:
  • 抑制剂
  • 代谢物
  • 抗体-一抗
  • 小分子
  • 试剂盒-Elisa试剂盒
  • 生化试剂
  • 9001-90-6
  • BF750标记的4-羟基壬烯醛抗体
  • IRDYE 800CW标记的4-羟基壬烯醛抗体
  • APC-CY5.5标记的4-羟基壬烯醛抗体
  • BIOTIN标记的4-羟基壬烯醛抗体
  • BF594标记的4-羟基壬烯醛抗体
  • HRP标记的4-羟基壬烯醛抗体
  • PERCP标记的4-羟基壬烯醛抗体
  • PE-CY5.5标记的4-羟基壬烯醛抗体
  • PE-CY5标记的4-羟基壬烯醛抗体
  • BF555标记的4-羟基壬烯醛抗体
  • CY3标记的4-羟基壬烯醛抗体
  • BF680标记的4-羟基壬烯醛抗体
  • APC-CY7标记的4-羟基壬烯醛抗体
  • PERCP-CY7标记的4-羟基壬烯醛抗体
  • APC标记的4-羟基壬烯醛抗体
  • PERCP-CY5.5标记的4-羟基壬烯醛抗体
  • BF700标记的4-羟基壬烯醛抗体
  • BF488标记的4-羟基壬烯醛抗体
  • RBITC标记的4-羟基壬烯醛抗体
  • BF350标记的4-羟基壬烯醛抗体
  • AP标记的4-羟基壬烯醛抗体
  • PACIFIC BLUE标记的4-羟基壬烯醛抗体
  • BF647标记的4-羟基壬烯醛抗体
  • BF405标记的4-羟基壬烯醛抗体
  • PE-CY7标记的4-羟基壬烯醛抗体
  • FITC标记的4-羟基壬烯醛抗体
  • CY5.5标记的4-羟基壬烯醛抗体
  • CY7标记的4-羟基壬烯醛抗体
  • CY5标记的4-羟基壬烯醛抗体
  • 4-羟基壬烯醛,10 MM DMSO 溶液
  • 4-HYDROXYNONENAL,LIPID PEROXIDATION MARKER
  • 4-羟基壬烯醛检测标准品
  • AF647标记的4-羟基壬烯醛抗体
  • PE标记的4-羟基壬烯醛抗体
  • 4-羟基壬烯醛抗体
  • 反式-4-羟基-2-壬烯醛
  • ANTI-4 HYDROXYNONENAL ANTIBODY-4-羟基壬烯醛抗体
  • 鱼4-羟基壬烯酸(4-HNE)ELISA试剂盒
  • 干冰运输]4-羟基壬烯醛
  • 4-羟基壬醛
  • (E)-4-羟基-2-壬烯醛
  • 4-羟基壬烯醛
  • 75899-68-2
  • 4-HNE/4-Hydroxynonenal
  • Mouse 4-Hydroxy-2-nonenal elisa kit
  • (±)4-Hydroxynon-2-enal
  • 4-Hydroxynonenal, 10 mM in DMSO
  • 4-Hydroxynonenal, Lipid peroxidation marker
  • Rabbit Anti-4 Hydroxynonenal/AF647 Conjugated antibody
  • Rabbit Anti-4 Hydroxynonenal/PE Conjugated antibody
  • Rabbit Anti-4 Hydroxynonenal antibody

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