ChemicalBook > CAS DataBase List > 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide

4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide

4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Structure
4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide
  • CAS No.1261576-81-1
  • Chemical Name:4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide
  • CBNumber:CB02750710
  • Molecular Formula:C25H24ClN3O3S2
  • Formula Weight:514.06
  • MOL File:1261576-81-1.mol
4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Property
  • Melting point 142-144 °C
  • Boiling point 718.4±70.0 °C(Predicted)
  • Density 1.370±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility DMSO: soluble10mg/mL, clear
  • form powder
  • pka 10.16±0.50(Predicted)
  • color white to beige
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301-H315-H319-H335
  • Precautionary statements P301+P310+P330-P302+P352-P305+P351+P338
4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: SML1007
  • Product name : B355252
  • Purity: ≥98% (HPLC)
  • Packaging: 50MG
  • Price: ₹29011
  • Updated: 2022/06/14
  • Buy: Buy

4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Chemical Properties,Usage,Production

  • Description B355252 is a neuroprotective agent. It potentiates NGF-induced neurite outgrowth in NS-1 cells (EC50 = ~1 μM). B355252 inhibits glutamate-induced excitotoxicity in HT-22 cells in a concentration-dependent manner and inhibits glutamate-induced decreases in GSH levels and increases in Bax levels, intracellular accumulation of calcium, and production of reactive oxygen species (ROS) in HT-22 cells when used at a concentration of 8 μM. It also inhibits decreases in cell viability, increases in ROS production, and mitochondrial membrane depolarization induced by 6-hydroxydopamine (6-OHDA; ) in HT-22 cells, an in vitro model of Parkinson’s disease.
  • Uses B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD)[1].
  • in vivo

    B-355252 (0.125 mg/kg; ip; daily; 3 days) significantly attenuates the infarct volume and protects post-stroke neuronal loss in adult male Sprague–Dawley rats with cerebral ischemia[1].

  • References [1] Hao-Kuang Wang, et al. A Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia. J Inflamm Res. 2021 Jun 1;14:2363-2376. DOI:10.2147/JIR.S303833
4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Suppliers
Global(41)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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  • Supplier： BOC Sciences
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4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide Spectrum
  • 抑制剂
  • 化合物B355252,10 MM DMSO 溶液
  • 化合物B355252
  • 1261576-81-1
  • B355252, 10 mM in DMSO
  • neurite outgrowth,ischemic neurons,HT22,B355252,glutamate,Inhibitor,Apoptosis,DNA damage,inhibit,B 355252,NGF,LDH level,ROS production,Parkinson disease,phenoxy thiophene sulfonamide,B-355252
  • 4-chloro-N-(1-naphthalenylmethyl)-5-[3-(1-piperazinyl)phenoxy]-2-thiophenesulfonamide
  • B355252 >=98% (HPLC)
  • 2-Thiophenesulfonamide, 4-chloro-N-(1-naphthalenylmethyl)-5-[3-(1-piperazinyl)phenoxy]-
  • B355252
  • 4-Chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide

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