ChemicalBook > CAS DataBase List > [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)

[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)

[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Structure
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
  • CAS No.909725-62-8
  • Chemical Name:[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)
  • CBNumber:CB02717540
  • Molecular Formula:C18H28F3N2O6P
  • Formula Weight:456.3936906
  • MOL File:909725-62-8.mol
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Property
  • storage temp. Store at -20°C
  • solubility Methanol: 0.1 mg/ml
  • form A crystalline solid
  • color White to off-white
  • UNSPSC Code 12352211
  • NACRES NA.25
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Chemical Properties,Usage,Production

  • Uses W146 is a selective antagonists of spingosine-1-phosphate receptor subtype 1.
  • Biological Activity W146 acts as an orthosteric antagonist. It is linked to blood lymphopenia and lung edema in mice.
  • in vivo

    W146 (5 mg/kg, ip, prior to AMD3100 administration) pre-treatment shows approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony forming assays, compared to that in mice treated with AMD3100 alone[3]
    The W146-mediated augmentation of KSL-HSPC mobilization is specific, because pretreatment of mice with W140 is unable to produce any effect on AMD3100-stimulated KSL-HSPC mobilization. Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count in mice[3].

    Animal Model:Mice (4-6-week-old)[3]
    .
    Dosage:5 mg/kg.
    Administration:IP, 1 hour prior to AMD3100 (ADM) administration.
    Result:Significantly increased in KSL-HSPC mobilization compared to that in mice pretreated with dextran followed by AMD3100 administration.
[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Preparation Products And Raw materials
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[(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate) Spectrum
909725-62-8, [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)Related Search:
  • 抑制剂
  • 脂类
  • C16H27N2O4PC2HF3O2
  • 化合物 W146 TFA
  • (R)-3-氨基 - (3-己基苯基氨基)-4-氧代丁基膦酸(TFA盐)
  • [(3R)-3-氨基-4-[(3-己基苯基)氨基]-4-氧代丁基]-膦酸单(三氟乙酸盐)
  • 909725-62-8
  • W146 TFA
  • (R)-3-AMINO-(3-HEXYLPHENYLAMINO)-4-OXOBUTYLPHOSPHONIC ACID (TFA SALT);W146
  • W146
  • (R)-3-AMino-(3-hexylphenylaMino)-4-oxobutylphosphonic acid (TFA salt)
  • [(3R)-3-Amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid mono(trifluoroacetate)

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