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PIPERAZINE DIHYDROCHLORIDE

CAS No.142-64-3
Chemical Name:PIPERAZINE DIHYDROCHLORIDE
CBNumber:CB0264741
Molecular Formula:C4H12Cl2N2
Formula Weight:159.06
MOL File:142-64-3.mol

PIPERAZINE DIHYDROCHLORIDE Property

Melting point 320°C(dec.)(lit.)
Boiling point 262.01°C (rough estimate)
Density 1.3011 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility Water
form White crystalline solid
color White to Off-White
InChI InChI=1S/C4H10N2.2ClH/c1-2-6-4-3-5-1;;/h5-6H,1-4H2;2*1H
InChIKey CVVIJWRCGSYCMB-UHFFFAOYSA-N
SMILES C1NCCNC1.Cl.Cl
LogP -1.171 (est)
CAS DataBase Reference 142-64-3(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) PIPERAZINE DIHYDROCHLORIDE
FDA UNII 17VU4Z4W88
EPA Substance Registry System Piperazine dihydrochloride (142-64-3)

Safety

Hazard Codes :Xn
Risk Statements :36/37/38-42/43
Safety Statements :22-26-36/37
OEB :B
OEL :TWA: 5 mg/m3
RTECS :TL4025000
F :3-10
HS Code :2933599550
Hazardous Substances Data :142-64-3(Hazardous Substances Data)
Toxicity :mouse,LD50,intraperitoneal,1970mg/kg (1970mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Japanese Journal of Pharmacology. Vol. 17, Pg. 475, 1967.

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H315-H319-H334-H361fd-H412
Precautionary statements P202-P261-P273-P302+P352-P305+P351+P338-P308+P313

PIPERAZINE DIHYDROCHLORIDE Price More Price(4)

Brand: TCI Chemicals (India)
Product number: P2491
Product name : Piperazine Dihydrochloride
Purity:
Packaging: 1G
Price: ₹3500
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P2491
Product name : Piperazine Dihydrochloride
Purity:
Packaging: 5G
Price: ₹8900
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P0450
Product name : Piperazine Dihydrochloride Monohydrate
Purity:
Packaging: 25G
Price: ₹1800
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: P0450
Product name : Piperazine Dihydrochloride Monohydrate
Purity:
Packaging: 500G
Price: ₹10800
Updated: 2022/05/26
Buy: Buy

PIPERAZINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses In the manufacture of fibers, pharmarceuticals, and insecticides.
Uses It is used as a one day wormer, either in water or feed, for the control of Round worms in poultry, swine, and horses. It also controls nodular worms in swine, and small strongyles in horses.
Uses Piperazine Dihydrochloride is an anthelmintic agent used in the treatment of parasitic worms in animals.
General Description White to cream-colored needles or powder. Mp: 318-20°C (with decomposition).
Reactivity Profile PIPERAZINE DIHYDROCHLORIDE is incompatible with the following: Water, HEAT, flames, oxidizers. PIPERAZINE DIHYDROCHLORIDE absorbs moisture from air. PIPERAZINE DIHYDROCHLORIDE may create flammable condition upon contact with HEAT, FLAMES and OXIDIZERS.
Safety Profile Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used in making fiber, pharmaceuticals, and insecticides. See also PIPERAZINE.
Potential Exposure Agricultural chemical, Suspected reprotoxic hazard. Piperazine is used to manufacture anthelmintics, antifilarials, antihistamines, and tranquilizers; the dihydrochloride is used in the manufacture of fibers, pharmaceuticals and insecticides. They are used as an intermediate in the manufacture of, pesticides, rubber chemicals and fibers. Also, piperazine is widely available, effective, and safe when used on an occasional basis against ascaride infections. It is also considerably cheaper than other anthelminthic drugs. In some countries where ascariasis is not endemic and where piperazine was used predominantly for the treatment of pinworn, it has been withdrawn from use on the grounds that other effective drugs are now available. Clinical dosages occasionally induce transient neurological signs and, in some circumstances, the drug may generate small amounts of nitrosamine in the stomach, which at considerably greater dosage in experimental animals has been demonstrated to have a carcinogenic potential.
Carcinogenicity Piperazine dihydrochloride is an irritant and sensitizer. Little information exists on the toxicology of piperazine dihydrochloride in humans or in animals. Acute human exposures to the dust have reportedly resulted in irritation to the eyes, mild to moderate skin burns, and sensitization. Exposure levels and duration were not available.
Purification Methods Crystallise the salt from aqueous EtOH and dry it at 110o. [Beilstein 23 III/IV 17, 23/1 V 30.]
Incompatibilities Aqueous solution is a strong base. Violent reaction with strong oxidizers and dicyanofurazan. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen compounds, carbon tetrachloride. Attacks aluminum, copper, nickel, magnesium and zinc.