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Boc-NH-PEG2-CH2COOH

Boc-NH-PEG2-CH2COOH Structure
Boc-NH-PEG2-CH2COOH
  • CAS No.108466-89-3
  • Chemical Name:Boc-NH-PEG2-CH2COOH
  • CBNumber:CB02639228
  • Molecular Formula:C11H21NO6
  • Formula Weight:263.29
  • MOL File:108466-89-3.mol
Boc-NH-PEG2-CH2COOH Property
  • Boiling point 425.7±30.0 °C(Predicted)
  • Density 1.145±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • pka 3.40±0.10(Predicted)
  • form liquid
  • color Yellow
  • InChI InChI=1S/C11H21NO6/c1-11(2,3)18-10(15)12-4-5-16-6-7-17-8-9(13)14/h4-8H2,1-3H3,(H,12,15)(H,13,14)
  • InChIKey OMBVJVWVXRNDSL-UHFFFAOYSA-N
  • SMILES C(O)(=O)COCCOCCNC(=O)OC(C)(C)C
  • UNSPSC Code 51171641
  • NACRES NA.22
Safety
  • HS Code  :2918999090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
Boc-NH-PEG2-CH2COOH Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 901577
  • Product name : t-Boc-N-amido-PEG2-CH2CO2H
  • Purity: ≥95%
  • Packaging: 50MG
  • Price: ₹2966.05
  • Updated: 2022/06/14
  • Buy: Buy

Boc-NH-PEG2-CH2COOH Chemical Properties,Usage,Production

  • Description t-Boc-N-amido-PEG2-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
  • Uses t-Boc-N-amido-PEG2-CH2CO2H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG2-CH2CO2H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
  • reaction suitability reagent type: linker
  • Synthesis To a stirred solution of 2-(2-(2-Aminoethoxy)ethoxy)acetic acid (5.0 g, 30.6 mmol) in 1,4-Dioxane (50 mL), Sodium carbonate (8.12 g, 76.5 mmol, dissolved in 10 mL water) and (Boc)2O (9.98 mL, 45.7 mmol) were added and stirred at room temperature for 12 h. The progress of the reaction was monitored by TLC. The reaction mass was partitioned between diethyl ether and water. Then, the aqueous layer was made acidic (pH = 3) by 3N HC1 solution and was extracted with DCM (2 x 200 mL). The organic layer was washed with water, and brine, dried over Na2504 and evaporated under reduced pressure to yield 50 g of pure Boc-NH-PEG2-CH2COOH (Yield:62.1 per cent).
  • IC 50 PEGs; Alkyl/ether
Boc-NH-PEG2-CH2COOH Preparation Products And Raw materials
Raw materials
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Boc-NH-PEG2-CH2COOH Spectrum
108466-89-3, Boc-NH-PEG2-CH2COOHRelated Search:
  • peg
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  • 高端化学
  • 助剂
  • 137978-97-5
  • 化合物 BOC-NH-PEG2-CH2COOH
  • 叔丁基二聚乙二醇乙酸
  • 氨基叔丁酯-二聚乙二醇-乙酸
  • 叔丁氧羰基-PEG2-乙酸
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  • 叔丁氧羰基二聚乙二醇羧甲基
  • T-BOC- N-酰胺基-PEG2-CH2CO2H
  • 2,2-二甲基-4-氧代-3,8,11-三氧杂-5-氮杂三烯-1,3-酸
  • 2-[2-[2-(BOC-氨基)乙氧基]乙氧基]乙酸
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  • 108466-89-3
  • N-(tert-Butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid
  • 2- [2- (tert butoxycarbonylamino) ethoxy] ethoxyacetic acid
  • t-Boc-<i>N</i>-amido-PEG<sub>2-</sub>CH<sub>2</sub>CO<sub>2</sub>H
  • Boc-NH-PEG2-CH2COOH/Boc-AEEA-OH
  • 2,2-dimethyl-4,13-dioxo-3,8,11-trioxa-5-azatetradecan-14-oic acid
  • 2-[2-(2-([(tert-butoxy)carbonylaminoJethoxy)ethoxylacetic acid
  • Boc-O 2 Oc-OH
  • N-Boc-8-amino-3,6-dioxaoctanoic acid
  • t-Boc-N-Amido-PEG2-CH2COOH
  • NHBoc-PEG2-CH2COOH
  • Boc-AEEA-OH
  • 2-[2-[2-[(2-Methylpropan-2-yl)oxycarbonylaMino]ethoxy]ethoxy]acetic acid
  • 2,2-DiMethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid
  • 2-diMethyl-4-oxo-
  • 11-Trioxa-5-azatridecan-13-oic acid
  • 3,8,11-Trioxa-5-azatridecan-13-oic acid, 2,2-diMethyl-4-oxo- USP/EP/BP
  • 3,6,11-Trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-
  • 2-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethoxy]acetic acid
  • 2-[2-[2-(Boc-amino)ethoxy]ethoxy]acetic Acid
  • T-BOC-NH-AMIDO-PEG2-CH2CO2H
  • BocNH-PEG2-CH2COOH
  • t-Boc-N-amido-PEG2-CH2CO2H
  • 8-tert-butyloxycarbonylaMino-3,6-dioxaoctanoic acid
  • 3,8,11-Trioxa-5-azatridecan-13-oic acid, 2,2-diMethyl-4-oxo-
  • t-boc-N-amido-PEG2-acetic acid
  • Boc-N-amido-PEG2-CH2CO2H

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