KF31327

Uses

Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitive phosphodiesterase-5 (PDE-5, IC50 of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2].

Biological Activity

Thioquinapiperifil (KF31327 free base) is a potent, selective, and noncompetitive inhibitor of phosphodiesterase (PDE-5) (IC50 of 0.074 nM) for sexual maturation studies.

in vitro

Thioquinapiperifil can be found in dietary supplements. Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation.

target

PDE5 0.074 nM (IC 50 )

PDE1 380 nM (IC 50 )

PDE2 670 nM (IC 50 )

PDE3 38 nM ( IC 50 )

PDE4 800 nM (IC 50 )

IC 50

PDE5: 0.074 nM (IC₅₀); PDE1: 380 nM (IC₅₀); PDE2: 670 nM (IC₅₀); PDE3: 38 nM (IC₅₀); PDE4: 800 nM (IC₅₀)

References

[1] Nahoko Uchiyama, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1331-4. DOI:10.1248/cpb.56.1331
[2] R Hirose, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001 Nov 9;431(1):17-24. DOI:10.1016/s0014-2999(01)01422-4