ChemicalBook > CAS DataBase List > NSC 366140

NSC 366140

NSC 366140 Structure
NSC 366140
  • CAS No.99009-20-8
  • Chemical Name:NSC 366140
  • CBNumber:CB01387979
  • Molecular Formula:C19H21N5O3
  • Formula Weight:367.4
  • MOL File:99009-20-8.mol
NSC 366140 Property
  • Boiling point 584.3±50.0 °C(Predicted)
  • Density 1.38±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C
  • pka 9.35±0.28(Predicted)
  • form Solid
  • color Light brown to orange
  • EWG's Food Scores 1
  • NCI Dictionary of Cancer Terms pyrazoloacridine
  • FDA UNII L24XJN68OW
  • NCI Drug Dictionary pyrazoloacridine
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

NSC 366140 Chemical Properties,Usage,Production

  • Uses Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC50 of 1.25 μM in K562 myeloid leukemia cells for 24 h treatment[1][2].
  • References [1] J S Sebolt, et al. Pyrazoloacridines, a new class of anticancer agents with selectivity against solid tumors in vitro. Cancer Res. 1987 Aug 15;47(16):4299-304. PMID:2440564
    [2] A A Adjei, et al. Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II. Clin Cancer Res. 1998 Mar;4(3):683-91. PMID:9533538
NSC 366140 Preparation Products And Raw materials
Raw materials
Preparation Products
NSC 366140 Suppliers
Global(18)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier： LGM Pharma
  • Tel：1-(800)-881-8210
  • Email：inquiries@lgmpharma.com
  • Country：United States
  • ProdList：2123
  • Advantage：70
  • Supplier： TargetMol Chemicals Inc.
  • Tel： 4008200310
  • Email：marketing@tsbiochem.com
  • Country：China
  • ProdList：24642
  • Advantage：58
NSC 366140 Spectrum
  • 抑制剂
  • 化合物PYRAZOLOACRIDINE,10 MM DMSO 溶液
  • 化合物PYRAZOLOACRIDINE
  • 化合物 T28475
  • NSC 366140 无结构图
  • 99009-20-8
  • Pyrazoloacridine, 10 mM in DMSO
  • Pyrazolo[3,4,5-kl]acridine-2(6H)-propanamine, 9-methoxy-N,N-dimethyl-5-nitro-
  • tumor,Inhibitor,leukemia,inhibit,solid,Apoptosis,NSC366140,carcinoma,Pyrazoloacridine,pancreatic,myeloid,Topoisomerase,PD115934
  • PD 115
  • Pd 115934
  • Pd 115,934
  • N,N-Dimethyl-9-methoxy-5-nitropyrazolo(3,4,5-kl)acridine-2(6H)-propanamine
  • Brn 4211902
  • 1,2,6,10b-Tetrahydro-5-nitro-9-methoxy-2-[3-(dimethylamino)propyl]pyrazolo[3,4,5-kl]acridine
  • Pyrazoloacridine
  • 9-Methoxy-N,N-dimethyl-5-nitropyrazolo[3,4,5-kl]acridine-2(6H)-propane-1-amine
  • 2,6-Dihydro-2-(3-dimethylaminopropyl)-9-methoxy-5-nitropyrazolo[3,4,5-kl]acridine
  • NSC 366140
  • (3-(9-METHOXY-5-NITRO-6H-PYRAZOLO(3,4,5-KL)ACRIDIN-2-YL)-PROPYL)-DIMETHYL-AMINE
  • Pyrazolo(3,4,5-kl)acridine-2(6H)-propanamine, N,N-dimethyl-9-methoxy-5-nitro-

Home

My