Biotin-C5-Azide

Uses

Biotin-C5-Azide (DecarboxyBiotin-N3) is a biotin reagent and can be used to prepare biotinylated conjugates[1]. Biotin-C5-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1] Pfaff P, et al. Azoacetylenes for the Synthesis of Arylazotriazole Photoswitches. J Am Chem Soc. 2021 Sep 15;143(36):14495-14501. DOI:10.1021/jacs.1c06014