5-Ph-IAA (0-10 mg/kg; intraperitoneally injection; every day; 7 days), used for the AID2 system , is sufficient to deplete mAID-BRD4 and TOP2A-mAC, leading to tumor suppression.
Animal Model: | Balb/c-nu female mice (7 weeks old; 16–20 g ) bearing mAID-BRD4 and TOP2A-mAC xenograft tumours cells |
Dosage: | 0 mg/kg, 1 mg/kg , 3 mg/kg and 10 mg/kg |
Administration: | Intraperitoneally injection; every day; 7 days |
Result: | Displayed significant tumor suppression of mAID-BRD4 xenografts and TOP2A-mAC xenografts . |