GLI1 antibody

Source

Rabbit

Reactivity

Human

Background

GLI was first identified as a gene amplified in a malignant glioma capable of transforming primary cells in cooperation with adenovirus E1A. GLI belongs to the Krüppel family of zinc finger proteins that includes three mammalian GLI proteins: GLI1, GLI2, and GLI3. These GLI proteins are similar to the Drosophila homolog Cubitus interruptus and function as transcription factors activated by the Hedgehog signaling pathway. Hedgehog signaling plays an important role in animal development, and research studies have shown that this pathway is aberrantly activated in many types of cancers.GLI1 itself is a transcriptional target of the Hedgehog signaling pathway and is used as a marker of Hedgehog signaling activation in cancer research.

References

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