ChemicalBook CAS DataBase List Ryngo 1-23

Ryngo 1-23

Product NameRyngo 1-23
CAS171674-76-3
CBNumberCB94718656
MFC23H20N4O8
MW480.43
MDL NumberMFCD32644553
MOL File171674-76-3.mol
MSDS FileSDS

Chemical Properties

Boiling point	1012.4±65.0 °C(Predicted)
Density	1.582±0.06 g/cm3(Predicted)
pka	8.00±0.15(Predicted)
form	Solid
color	Light yellow to yellow

Ryngo 1-23 Price

Product number	Packaging	Price	Product description	Buy
Cayman Chemical 44119	1mg	$63	Bis-T-23 ≥90%	Buy
Cayman Chemical 44119	5mg	$268	Bis-T-23 ≥90%	Buy
Cayman Chemical 44119	10mg	$504	Bis-T-23 ≥90%	Buy
Biosynth WGA67476	25mg	$1237.25	1,3-Bis(2-cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamino)propane	Buy
Biosynth WGA67476	50mg	$1721	1,3-Bis(2-cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamino)propane	Buy

Ryngo 1-23 Chemical Properties,Usage,Production

Description

AG 1717, also known as Bis-T-23, is a promoter of actin-dependent dynamin oligomerization. It acts by increasing actin polymerization in injured podocytes.

Uses

Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD)[1][2].

in vivo

Bis-T-23 (AG1717) (1 ng) targets actin-dependent dynamin oligomerization in podocytes to promote proper GFB function^[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorate proteinuria by altering actin dynamics^[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorates or prevented proteinuria and diminished mesangial matrix expansion in diverse genetic and chronic models of glomerular disease in rodents^[1].

Animal Model:	Sprague-Dawley rats (8 weeks old, males); Mice^[1]
Dosage:	20, 40 mg/kg; 40 mg/kg
Administration:	Intraperitoneal injection; signle, once for 6 consecutive days
Result:	Specifically reduced proteinuria on days 18 and 24. Caused a transient reduction of proteinuria (single dose) in PKCε^KO mice. Completely prevented the onset of high-level proteinuria in the CD2AP^KO mice. Significantly extended the lifespans of CD2AP^KO mice. Led to improved glomerular histology with less mesangial matrix accumulation.

Animal Model:	Zebrafish^[1]
Dosage:	1 ng
Administration:	Injection
Result:	Promoted oligomerization of zebrafish Dyn2. Increased the number of focal adhesions (FAs) and stress fibers in cultured podocytes.

References

[1] Schiffer M, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015;21(6):601-609. DOI:10.1038/nm.3843
[2] Mazumder, A.,et al. Effects of Tyrphostins, Protein Kinase Inhibitors, on Human Immunodeficiency Virus Type 1 Integrase. Biochemistry, 1995, 34(46), 15111–15122.

Preparation Products And Raw materials

Ryngo 1-23 Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65
Shanghai Beckham Medical Technology Co., Ltd	13816613772	huahero21@sina.com	China	2996	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	18916372613	yanzihan@shyuanye.com	China	87240	60
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	9774	55
MQ (shanghai) Pharmaceuticals Co., Ltd.	13761635123	sales@linyuepharm.com	China	5760	55
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6288	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	11975	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9831	58

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