Description
trans-Petroselinic acid is the
trans isomer of petroselinic acid (Item no.
20024) and an isomer of oleic acid that has been found in cow, goat, and ewe milk fat as well as human breast milk. In HepG2 cells,
trans-petroselinic acid (100 μM) increases cellular content of triacylglycerols and cholesterol esters and upregulates transcription of genes involved in fatty acid synthesis, including
SREBP-1c,
ACACA,
FASN, and
SCD1, and cholesterol synthesis, including
HMGCR,
HMGCS1,
FDFT1, and
SREBP-2.
Uses
(6E)-6-Octadecenoic Acid, can be used in Inhibitors of appressorium formation in Magnaporthe grisea, a new approach to control rice blast disease.
Definition
ChEBI: The trans-isomer of octadec-6-enoic acid, a long-chain fatty acid.
References
[1] DIETZ PRECHT. Comparative studies on individual isomeric 18∶1 acids in cow, goat, and ewe milk fats by low-temperature high-resolution capillary gas-liquid chromatography[J]. Lipids, 2001, 36 8: 827-832. DOI:
10.1007/s11745-001-0791-8[2] SIMONE HAUFF Walter V. Quantitation of cis- and trans-Monounsaturated Fatty Acids in Dairy Products and Cod Liver Oil by Mass Spectrometry in the Selected Ion Monitoring Mode[J]. Journal of Agricultural and Food Chemistry, 2009, 57 9: 3423-3430. DOI:
10.1021/jf803665u[3] PAYAM VAHMANI. Comparing the lipogenic and cholesterolgenic effects of individual trans-18:1 isomers in liver cells[J]. European Journal of Lipid Science and Technology, 2016, 119 3. DOI:
10.1002/ejlt.201600162
