Piperacillin (100 mg/kg, i.v., 4 times a day, 5 d) hydrate in combination with Tazobactam (HY-B1418)(12.5 mg/kg, i.v., 4 times a day, 5 d) prolongs survival in mice with low inoculum of K. pneumoniae[3].
| Animal Model: | BALB/c low inoculum model of K. pneumoniae, KEN-11 strain[3]. |
| Dosage: | 100 mg/kg |
| Administration: | Intravenous injection (i.v.), 4 times a day, 5 d, in combination with Tazobactam (12.5 mg/kg, i.v., 4 times a day, 5 d) |
| Result: | Enabled all mice survived whereas all control mice died by 5 d, decreased the number of bacteria in lungs compared with control group.
Observed no bacteria in the blood of most mice (except for two mice at the early phase) while bacteria were observed in the blood of control group.
Observed few inflammatory cells in the alveoli whereas an influx of numerous inflammatory cells were observed in the control group.
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