Pseudocoptisine chloride
- Product NamePseudocoptisine chloride
- CAS30044-78-1
- CBNumberCB93340603
- MFC19H14ClNO4
- MW355.77
- EINECS-0
- MDL NumberMFCD33548929
- MOL File30044-78-1.mol
Chemical Properties
storage temp. | Store at -20°C |
Pseudocoptisine chloride Price
Product number | Packaging | Price | Product description | Buy |
---|---|---|---|---|
ChemScene CS-0158969 | 5mg | $300 | Pseudocoptisinechloride 99.17% |
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ChemScene CS-0158969 | 10mg | $480 | Pseudocoptisinechloride 99.17% |
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ChemScene CS-0158969 | 25mg | $950 | Pseudocoptisinechloride 99.17% |
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ChemScene CS-0158969 | 50mg | $1450 | Pseudocoptisinechloride 99.17% |
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ChemScene CS-0158969 | 100mg | $2250 | Pseudocoptisinechloride 99.17% |
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Pseudocoptisine chloride Chemical Properties,Usage,Production
Biological Activity
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects.in vitro
Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells.
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions.
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells.
in vivo
The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, ip) are examined. Pseudocoptisine (2.0 mg/kg, po) significantly reverses cognitive impairments in mice by passive avoidance test.
Preparation Products And Raw materials
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Pseudocoptisine chloride Spectrum
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