IMR-1A

Product NameIMR-1A
CAS331862-41-0
CBNumberCB93133188
MFC13H11NO5S2
MW325.36
EINECS-0
MDL NumberMFCD04083080
MOL File331862-41-0.mol

Chemical Properties

Density	1.55±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO:4.0(Max Conc. mg/mL);12.29(Max Conc. mM) Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM)
pka	3.10±0.10(Predicted)
form	Solid
color	Light yellow to yellow

IMR-1A Price

Product number	Packaging	Price	Product description	Buy
ChemScene CS-5752	5mg	$420	IMR-1A 98.23%	Buy
ChemScene CS-5752	10mg	$600	IMR-1A 98.23%	Buy
ChemScene CS-5752	50mg	$1800	IMR-1A 98.23%	Buy
ChemScene CS-5752	100mg	$2520	IMR-1A 98.23%	Buy
CSNpharm CSN18826	100mg	$2016	IMR-1A	Buy

IMR-1A Chemical Properties,Usage,Production

Biological Activity

IMR-1A is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. It has antitumor activity.

in vivo

IMR-1A (2 mg/kg (iv) and 100 mg/kg (ip)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/ 2) of 2.22 h following a single iv administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration.

< td class="col1 fwb"> Administration:

Animal Model:	Male C57 BL/6 mice
Dosage:	2 mg/kg (iv) and 100 mg/kg (ip)
Iv and ip
Result:	Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single iv administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration.

target

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Preparation Products And Raw materials

IMR-1A Supplier

Target	Value
Notch (Cell-free assay)	0.5 μM
Notch (Cell-free assay)	2.9 μM(Kd)

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai JiYi Biotechnology Co. Ltd.	13621943973	sales@shjiyipharmatech.com	China	1166	55

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IMR-1A Spectrum

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