General Description
A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos.
553502 &
553508) in inhibiting PDGF-BB- (Cat. No.
521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 μM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 μM). Also available in InSolution format (Cat. No.
553512).
