Uses
WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM[1]. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[2].
References
[1] Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. DOI:
10.1038/sj.npp.1301503[2] Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. DOI:
10.1016/j.ejphar.2011.04.028[3] DEREK C. COLE. Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT6 Receptor Agonist[J]. Journal of Medicinal Chemistry, 2007, 50 23: 5535-5538. DOI:
10.1021/jm070521y[4] GREGORY V CARR I L Lee E Schechter. Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats.[J]. Psychopharmacology, 2011, 213 2-3: 499-507. DOI:
10.1007/s00213-010-1798-7
