Description
Prostaglandin E
2 (PGE
2), one of the most widely investigated PGs, can be used as a biomarker of inflammation, disease state, or therapeutic effectiveness. However due to its rapid metabolism, direct measurement of PGE
2 in biological samples is difficult. The major urinary metabolite of PGE
2, tetranor-
PGEM, serves as an indirect marker of PGE
2 biosynthesis. Though like PGE
2, tetranor-
PGEM is also chemically unstable. tetranor-
PGAM is a dehydration product of tetranor-
PGEM and can be measured as a surrogate for tetranor-
PGEM levels in urine.
