Synthesis
The general procedure for synthesizing ethyl 2-phenylethylacetoacetate from ethyl acetoacetate and β-bromophenylethane is as follows: with reference to Example 3, the operation is the same as that of Reference Example 1, except that 55.5 g (300 mmol) of β-bromophenylethane, 42.9 g (330 mmol) of ethyl acetoacetate, 27.8 g of toluene, 103 g (748 mmol) of potassium carbonate, and 2.08 g of water as reactants. Upon completion of the reaction, 77.4 g of ethyl 2-phenylethyl acetoacetate crude product was obtained. The crude product was analyzed to contain 68.9 wt% of ethyl 2-phenylethylacetoacetate in 77% yield.
References
[1] Patent: EP937703, 1999, A1
[2] Farmaco, Edizione Scientifica, 1988, vol. 43, # 12, p. 989 - 1003
[3] Bulletin de la Societe Chimique de France, 1964, p. 27 - 30
[4] Journal of the Chemical Society. Perkin Transactions 2, 1998, # 7, p. 1635 - 1641
