Uses
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
Biological Activity
TACR3 (tachykinin receptor 3) is a receptor for NKB (neurokinin B), and upon activation results in coupling to Gq proteins. This results in the activation of inositol phosphate (IP) and protein kinase C signaling pathways. It is thought to be the autocrine regulator of kisspeptin release, which is a secretagogue of GnRH (gonadotropin-releasing hormone). Loss of function mutation in TACR3 and NKB are associated with GnRH deficiency, which is a disorder characterized by failure to undergo puberty due to low sex steroid hormone levels. In postmenopausal women TACR3 and NKB are involved in estrogen negative feedback, where they control LH (luteinizing hormone) release. His148Leu mutation in this gene results in hypogonadotropic hypogonadism, which is present in the first extracellular loop of this receptor. Polymorphisms in this gene are linked with alcohol and cocaine dependence.
