ANTI-K+/CL- COTRANSPORTER (KCC2)

Uses

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)

General Description

Transporters and exchangers play a critical role in the generation and dissipation of action potentials in nerve cells and in the maintenance of normal cell volume. They are also involved in a variety of mechanisms pertaining to the control of neuronal growth, maturation, synaptic plasticity and neuroendocrine functions
The cation-chloride cotransporters (CCCs) are glycoproteins involved in transport of ions, including chloride, across the cell membrane without an accompanying net charge movement; thus this type of transport is driven without the direct hydrolysis of ATP. The energy for the transport is derived from the cation gradient generated by the Na⁺/K⁺/ATPase. The CCCs also play a critical role in influencing GABA- and glycine-mediated signaling. Other transporters that participate in chloride homeostasis include Na⁺-dependent and Na⁺-independent anion exchangers, which exchange chloride for HCO3^- ions
Three cotransporters belonging to this family include sodiumchloride( Na⁺/Cl^-/ ) cotransporters (NCCs), sodiumpotassium-chloride (Na⁺/K⁺/2Cl^-) cotransporters (NKCCs) and potassium-chloride (K⁺/Cl^-) cotransporters (KCCs). K⁺/Cl^- cotransporter (KCC2) is the major neuronal chloride transporter. It has been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). GABA-mediated fasthyperpolarizing inhibition depends on extrusion of chloride by KCC2 In conditions of neuronal damage, where neuronal excitability is increased, and in spinal cord in models of neuropathic pain, the expression of the KCC2 transporter is decreased