2-chloro-3-(4-chloro[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)-6-quinolinyl methyl ether

Biological Activity

STING agonist 1a is an agonist of stimulator of interferon genes (STING).1 It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50 = 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .

References

1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020)