Uses
Monoclonal Anti-Uvomorulin/E-Cadherin antibody produced in rat has been used in various immunochemical techniques including immunoblotting, immunoprecipitation, immunohistochemical staining and immunofluorescent staining.
General Description
Monoclonal Anti-Uvomorulin/E-Cadherin (rat IgG1 isotype) is derived from the DECMA-1 hybridoma produced by the fusion of rat myeloma cells and splenocytes from an immunized Lou rat. Uvomorulin/E-Cadherin (Epithelial cadherin), also known as CDH1, CAM 120/80, L-CAM (Cell-Adhesion Molecule) or CD324, is a member of the cadherin transmembrane glycoproteins superfamily. It is characterized with a highly conserved cytoplasmic tail.
Biochem/physiol Actions
E-cadherin is a calcium-dependent glycoprotein. It is responsible for the homogeneous attachment between cells. It suppresses malignant transformation of tumors. Additionally, it also regulates cellular invasion and metastasis.
