Description
(R)-CCG-1423 is a stereoisomer of CCG-1423 , a Rho inhibitor that blocks signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF).
1,2 The R-isomer of CCG-1423 inhibits MRTF-A-dependent cellular events, including SRF-mediated gene expression and cell migration, less potently than the S-isomer.
2
References
1. Evelyn, C.R., Wade, S.M., Wang, Q., et al.
CCG-1423: A small-molecule inhibitor of RhoA transcriptional signaling Mol. Cancer Ther. 6(8),2249-2260(2007).
2. Watanabe, B., Minami, S., Ishida, H., et al.
Stereospecific inhibitory effects of CCG-1423 on the cellular events mediated by myocardin-related transcription factor A PLoS One 10(8),(2015).
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