Description
NT1-O14B is a tryptamine-containing ionizable cationic lipidoid.
1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing NT1-O14B and the cationic lipidoid 306-O12B-3 encapsulating antisense oligonucleotides (ASOs) against tau decreases tau brain levels in mice.
References
1. Ma, F., Yang, L., Sun, Z., et al.
Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection Sci. Adv. 6(30),eabb4429(2020).
