Hydrazinecarbothioamide, 2-[1-(3-bromophenyl)propylidene]-

Description

Bromo-PTC (443144-54-5) is a potent inhibitor of cruzain (IC50 = 100 nM). Cruzain is the major cysteine protease of Trypanosoma cruzi, the protozoan parasite responsible for American trypanosomiasis or Chagas’ disease. Cruzain is essential for the replication of the parasite and thus is a new target for antitrypanosomal chemotherapy. Bromo-PTC exhibits trypanocidal activity in cultured host cells without toxicity1.

References

1) Xaohui et al. (2002), Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain; J. Med. Chem., 45 2695