Uses
Doxycycline calcium, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline calcium shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline calcium can be used to construct gene expression regulation models[1][2][3][4][5].
Veterinary Drugs and Treatments
Although there are no veterinary-approved doxycycline products
available, its favorable pharmacokinetic parameters (longer halflife,
higher CNS penetration) when compared to either tetracycline
HCl or oxytetracycline HCl make it a reasonable choice to use in
small animals when a tetracycline is indicated, particularly when a
tetracycline is indicated in an azotemic patient.
References
[1] Eusebio Manchado, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016 Jun 30;534(7609):647-51. DOI:
10.1038/nature18600[2] Anna-Luisa Luger, et al. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5):1504. DOI:
10.3390/ijms19051504[3] Wilfried Briest, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337(3):621-7. DOI:
10.1124/jpet.110.177782[4] Ethan Ahler, et al. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013 May 31;8(5):e64561. DOI:
10.1371/journal.pone.0064561[5] Le Zhang, et al. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer. Cell Cycle. 2017 Apr 18;16(8):737-745. DOI:
10.1080/15384101.2016.1241929[6] Manfredsson FP, et al. Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Mol Ther. 2009 Nov;17(11):1857-67. DOI:
10.1038/mt.2009.196[7] Kistner A, et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10933-8. DOI:
10.1073/pnas.93.20.10933[8] Niv Y. Doxycycline in Eradication Therapy of Helicobacter pylori--a Systematic Review and Meta-Analysis. Digestion. 2016;93(2):167-73. DOI:
10.1159/000443683
