ChemicalBook CAS DataBase List 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt

1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt

Product Name1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt
CAS17795-21-0
CBNumberCB8909257
MFC5H4N4O.Na
MW159.1
EINECS241-771-5
MDL NumberMFCD12965022
MOL File17795-21-0.mol
MSDS FileSDS

Chemical Properties

storage temp.	Sealed in dry,Room Temperature
form	Solid
pka	9.31(at 25℃)
color	White to off-white
FDA UNII	428673RC2Z
NCI Drug Dictionary	allopurinol sodium

1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Price

Product number	Packaging	Price	Product description	Buy
ChemScene CS-0013303	25mg	$115	Allopurinol sodium ≥98%	Buy
ChemScene CS-0013303	50mg	$194	Allopurinol sodium ≥98%	Buy
ChemScene CS-0013303	100mg	$329	Allopurinol sodium ≥98%	Buy
Matrix Scientific 091150	1.00g	$227	Sodium 1H-pyrazolo[3,4-d]pyrimidin-4-olate	Buy
Matrix Scientific 091150	5.00g	$605	Sodium 1H-pyrazolo[3,4-d]pyrimidin-4-olate	Buy

1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Chemical Properties,Usage,Production

Uses

Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect[1][2][3][4][5].

in vivo

Allopurinol sodium (39 mg/kg; p.o.; daily for 21 successive days) shows anti-depressant activity in mouse^[3].
Allopurinol sodium (10-400 mg/kg; i.p.) induces anti-nociception activity in mouse^[4].

Animal Model:	20-30 g, male Swiss Albino mice^[3]
Dosage:	39 mg/kg
Administration:	P.o.; daily for 21 successive days
Result:	Reduced the immobility time in the FST with the immobility time of 129.8±10.5 s.

Animal Model:	30-40 g, male adult Swiss albino mice^[4]
Dosage:	10, 50, 100, 200, 400 mg/kg
Administration:	I.p.
Result:	Produced dose-dependent anti-nociception in the tail-flick, hot-plate.

References

[1] Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006;58(1):87-114. DOI:10.1124/pr.58.1.6
[2] Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472. DOI:10.1128/AAC.5.5.469
[3] Karve AV, et al. Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice. Indian J Pharmacol. 2013 May-Jun;45(3):244-7. DOI:10.4103/0253-7613.111922
[4] Schmidt AP, et al. Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors. Br J Pharmacol. 2009 Jan;156(1):163-72. DOI:10.1111/j.1476-5381.2008.00025.x
[5] Sun Y, et al. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS One. 2015 Apr 1;10(4):e0123649. DOI:10.1371/journal.pone.0123649

Preparation Products And Raw materials

1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Shanghai civi chemical technology co.,Ltd	86-21-34053660	sale@labgogo.com	China	9853	52
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2774	58
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10628	60
AdooQ Bioscience CHINA	025-58849295	info@adooq.cn	China	2981	60
Hubei Jusheng Technology Co.,Ltd	027-59599241 18871490274	1400878000@qq.com	China	9491	58
BOC Sciences	16314854226	info@bocsci.com	United States	9909	65
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	87240	60
Shanghai QianYan Bio-technology Co., Ltd	02781293128	orders@biochemsafebuy.com	China	9904	55
Target molecule Corp.	857-239-0968	service1@targetmol.com	United States	2548	60

View Latest Prices from 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt manufacturers

1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Spectrum

17795-21-0, 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium saltRelated Search

Send Inquiry