Cyclophosphamide Impurity 20

Uses

N-?(2-?Chloroethyl)?-?N-?(2-?ethoxyethyl)?tetrahydro-2H-?1,?3,?2-?Oxazaphosphorin-?2-?amine 2-?Oxide is an impurity of Cyclophosphamide (C988580), a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.