Bleselumab
- Product NameBleselumab
- CAS1453067-91-8
- CBNumberCB88080949
- MW0
- MOL FileMol file
- MSDS FileSDS
Bleselumab Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0620824 | 1mg | $325 | Bleselumab 98.97% |
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| ChemScene CS-0620824 | 5mg | $845 | Bleselumab 98.97% |
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| ChemScene CS-0620824 | 10mg | $1354 | Bleselumab 98.97% |
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| aablocks AA02AP4U | 1mg | $572 | Bleselumab ≥95%(SDS-PAGE&SEC-HPLC) |
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| aablocks AA02AP4U | 5mg | $1500 | Bleselumab ≥95%(SDS-PAGE&SEC-HPLC) |
Buy |
Bleselumab Chemical Properties,Usage,Production
Uses
Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (Kd: 0.24nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection[1].in vivo
Bleselumab (0.1-10mg/kg, i.v.) inhibits Delayed-type hypersensitivity (DTH) reaction in cynomolgus monkeys[2].
Bleselumab (2 mg/kg, i.v.) prolongs renal allograft survival in Cynomolgus monkeys[3].
Bleselumab (2 or 5 mg/kg, i.v.) together with Tacrolimus (HY-13756) shows a longer median survival time (MST) than monotherapy[3].
| Animal Model: | Cynomolgus monkeys[2]. |
| Dosage: | 0.1, 1 and 10mg/kg |
| Administration: | Intravenous injection (i.v.) |
| Result: | Inhibited anti-TTx IgG and anti-TTx IgM productions in a concentration-dependent manner. |
References
[1] Harland RC, et al. Efficacy and safety of bleselumab in kidney transplant recipients: A phase 2, randomized, open-label, noninferiority study. Am J Transplant. 2020 Jan;20(1):159-171. DOI:10.1111/ajt.15591[2] Okimura K, et al. Characterization of ASKP1240, a fully human antibody targeting human CD40 with potent immunosuppressive effects. Am J Transplant. 2014 Jun;14(6):1290-9. DOI:10.1111/ajt.12678
[3] Song L, et al. Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys. Transplantation. 2014 Aug 15;98(3):267-76. DOI:10.1097/TP.0000000000000236
Preparation Products And Raw materials
Bleselumab Suppliers
Global(16)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 | |
| 177-54423994 17754423994 |
2853530910@QQ.com | China | 7996 | 62 | |
| 15817493340 | 981810490@qq.com | China | 1577 | 58 | |
| 027-65317797 15926423062 |
422450190@qq.com | China | 10302 | 58 | |
| 027-65279366 18108604356 |
products@biolabreagent.com | China | 9864 | 58 | |
| 13720134139 086-15871494362 13720134139 |
orders@jknbiochem.com | China | 7284 | 58 | |
| 021-65675885 18964387627 |
customer_service@efebio.com | China | 11963 | 58 | |
| 027-027-16602739303 16602739303 |
673003916@qq.com | China | 4622 | 58 | |
| 15111215862 18229892877 |
3062105966@qq.com | China | 5571 | 58 | |
| 17316404525 17316404525 |
209533805@qq.com | China | 9772 | 58 |
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