Description
18:0 DDAB is a double-chained quaternary ammonium surfactant with a bromide counter ion.
Chemical Properties
white powder
Uses
Dimethyldioctadecylammonium bromide has been used in a study to assess the interaction of its monolayers with DNA using specular neutron reflection, surface pressure-area isotherms, and Brewster angle microscopy. It has also been used in a study to investigate new adjuvants for use in kill vaccines for bovine viral diarrhea virus (BVDV).
General Description
18:0 DDAB is cationic lipid and a quaternary ammonium salt. The hydrocarbon tails are saturated unlike the ionizable lipids.
Biochem/physiol Actions
18:0 DDAB is a surface-active molecule, used as an adjuvant to induce systemic immune response. It is non-toxic.
Purification Methods
Crystallise the bromide from acetone, then MeOH [Lukac J Am Chem Soc 106 4387 1984]. Also purify it by chromatography on alumina by washing with *C6H6 and eluting with Me2CO, evaporating and crystallising from MeCN [Swain & Kreevoy J Am Chem Soc 77 1126 1955]. [Beilstein 4 IV 829.]
