Description
Nitrotyrosine is formed by peroxynitrite-
mediated nitration of protein tyrosine residues. Its presence on proteins can be used as a marker for peroxynitrite formation
in vivo. Both free and protein-
bound nitrotyrosine are commonly found in mammalian tissues and are increased in pathological conditions. The basal levels of free nitrotyrosine in human plasma is approximately 3 nM as determined by gas chromatography/mass spectrometry.
Chemical Properties
ochre-yellow to yellow-green powder
Uses
3-Nitro-L-tyrosine is used as an indicator of the formation of peroxynitrite by NO-dependent oxidative damage.
Uses
A marker for peroxynitrite. Oxidant and cytotoxic agent.
Definition
ChEBI: 3-nitro-L-tyrosine is a 3-nitrotyrosine comprising L-tyrosine having a nitro group at the 3-position on the phenyl ring. It is a L-tyrosine derivative, a non-proteinogenic L-alpha-amino acid and a 3-nitrotyrosine. It is an enantiomer of a 3-nitro-D-tyrosine.
Biochem/physiol Actions
Oxidant and cytotoxic agent.
