Description
Nitrotyrosine is formed by peroxynitrite-
mediated nitration of protein tyrosine residues. Its presence on proteins can be used as a marker for peroxynitrite formation
in vivo. Both free and protein-
bound nitrotyrosine are commonly found in mammalian tissues and are increased in pathological conditions. The basal levels of free nitrotyrosine in human plasma is approximately 3 nM as determined by gas chromatography/mass spectrometry.
References
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