PE 22-28 Chemical Properties,Usage,Production
Description
PE 22-28 is a peptide inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (IC50 = 0.1 nM in HEK293 cells expressing the human channel) and a fragment of spadin. It is selective for K2P2.1/TREK1 over K2P10.1 /TREK2, K2P13.1/TRAAK, K2P18.1/TRESK, and K2P3.1/TASK1 in HEK293 cells expressing the human channels at 100 nM. It promotes neurogenesis, increasing Psd-95 levels in mouse hippocampi and enhancing synaptogenesis. At 0.3 μg/kg for four days, PE 22-28 improves mouse behavior in tests like the forced swim test, novelty-suppressed feeding, and Porsolt learned helplessness test, suggesting potential for treating depression.Preparation Products And Raw materials
PE 22-28 Suppliers
Global(22)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
+8619031013551 | ably@aljbio.com | China | 145 | 58 | |
+8618873369619 | dingchengbusiness8@163.com | China | 260 | 58 | |
16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 | |
+86-8621-54707036 +8613917132737 |
api-specialist@wayxbio.com | China | 243 | 58 | |
+86-16632312509 +86-16632315022 |
saixinkeji@aliyun.com | China | 90 | 58 | |
+44-7438349267 +44-7438349267 |
xena@healthtide-api.com | China | 559 | 58 | |
+86-17380623303 +86-17380623303 |
Caroline@youngshechem.com | China | 4861 | 58 | |
0571-87213919 | eric@peptidego.com | China | 6756 | 58 | |
0510-85629785 18013409632 |
sales@reading-chemicals.com | China | 14081 | 58 | |
0571-88211921 13355716090 |
Sales@gotopbio.com | China | 2851 | 58 |
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